Evidence map›Paper›PMID 41575689›Full record

ReviewMolecular biology reports2026

UFMylation in lipid metabolism disorders-associated diseases.

Zi-Ping Ning, Ya-Ling Tang, Lin Cao, Hong-Feng Gu

Abstract readReview
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In one paragraph

Review in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zi-Ping NingDepartment of Physiology & Institute of Neuroscience, Hengyang Medical College, University of South China, Hengyang, 421001, Hunan, People's Republic of China.
Ya-Ling TangDepartment of Physiology & Institute of Neuroscience, Hengyang Medical College, University of South China, Hengyang, 421001, Hunan, People's Republic of China.
Lin CaoDepartment of Neurology, Hengyang Medical School, The Affiliated Nanhua Hospital, University of South China, Hengyang, 421001, Hunan, People's Republic of China. 4009072@qq.com.
Hong-Feng GuDepartment of Physiology & Institute of Neuroscience, Hengyang Medical College, University of South China, Hengyang, 421001, Hunan, People's Republic of China. ghf513@usc.edu.cn.

Funding

National Key Clinical Specialty Scientific Research Project grants No. Z2023159National Natural Science Foundation of China grants No. 81500349
6 · The paper itself

Abstract

Lipid metabolism is a finely regulated process essential for cellular homeostasis, and its dysregulation contributes to various diseases, such as atherosclerosis and obesity. UFMylation, a ubiquitin-like posttranslational modification involving UFM1 conjugation to target proteins, has emerged as a critical regulator of lipid metabolism. This review systematically outlines the UFMylation cascade, including its enzymatic components (UFSPs, UBA5, UFC1, and UFL1), and its physiological roles in lipid metabolism, endoplasmic reticulum homeostasis, DNA repair, and tissue development. We further highlight the pathogenic implications of UFMylation dysregulation in lipid-related disorders, including atherosclerosis (AS), nonalcoholic fatty liver disease (NAFLD), type 2 diabetes mellitus(T2DM), and cancer, by modulating lipogenesis, lipolysis, and cholesterol efflux. Furthermore, this review underscores UFMylation as a pivotal mechanism in lipid metabolism disorders and proposes directions for mechanistic and translational studies.

Indexed as

Lipid MetabolismLipid Metabolism DisordersProtein Processing, Post-TranslationalAnimalsAtherosclerosisDiabetes Mellitus, Type 2HumansNon-alcoholic Fatty Liver DiseaseProteinsUbiquitinationUbiquitinsProteinsUbiquitinsUFM1 protein, humanAtherosclerosisCancerLipid metabolismNonalcoholic fatty liver diseaseType 2 diabetes mellitusUFMylation

Identifiers

PMID41575689

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.