Evidence map›Paper›PMID 41575850›Full record

ArticleCell reports2026

HP1γ self-assembles and cooperates with KAP1 in repression of long noncoding RNA AI662270 in ESCs.

Nitika Gaurav, Weihua Qin, Karthik Selvam, Ziling Zhou, Jiuyang Liu, Yanshuang Yin, Rohit K Singh, Ryan A O'Hara, Zohreh Tavaf, Amarjeet Kumar and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Nitika GauravDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Weihua QinDepartment of Biology II, Ludwig-Maximilians-Universität München, 81377 München, Germany.
Karthik SelvamDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Ziling ZhouDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
Jiuyang LiuDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Yanshuang YinDepartment of Biology II, Ludwig-Maximilians-Universität München, 81377 München, Germany.
Rohit K SinghDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Ryan A O'HaraCecil H. and Ida Green Center for Reproductive Biology Sciences, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Zohreh TavafDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Amarjeet KumarInstitute for Quantum Life Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan.
Hidetoshi KonoInstitute for Quantum Life Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan; Graduate School of Science and Engineering, Chiba University, Chiba 263-8522, Japan.
Geeta J NarlikarDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
Laura A BanaszynskiCecil H. and Ida Green Center for Reproductive Biology Sciences, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Heinrich LeonhardtDepartment of Biology II, Ludwig-Maximilians-Universität München, 81377 München, Germany. Electronic address: h.leonhardt@lmu.de.
Tatiana G KutateladzeDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address: tatiana.kutateladze@cuanschutz.edu.

Funding

UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeffrey M Zigman · 2022 to 2026
$7.4M
Measuring the lifetime and mechanical stability of phase-separated heterochromatin domainsR35GM127020 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GEETA J NARLIKAR · 2018 to 2026
$7.3M
Chromatin Dynamics and Genome RegulationR35GM124958 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Laura Banaszynski · 2017 to 2026
$4.4M
Mechanisms of p300 Activation During Pluripotency and Differentiation.R01HD109239 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI Laura Banaszynski · 2022 to 2026
$2.1M
Targeting acetylated histone H4 by MLL4R01AG067664 · NIA · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2021 to 2025
$2.1M
Molecular analysis of ASH1LR01CA252707 · NCI · UNIVERSITY OF COLORADO DENVER · PI TATIANA G KUTATELADZE · 2020 to 2026
$1.9M
Understanding MORF-mediated hematological gene regulatory mechanismsR01GM157928 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI TATIANA G KUTATELADZE · 2025 to 2026
$775k
NCI NIH HHS R01 CA252707NIA NIH HHS R01 AG067664NICHD NIH HHS R01 HD109239NIDDK NIH HHS P30 DK127984NIGMS NIH HHS R01 GM157928NIGMS NIH HHS R35 GM124958NIGMS NIH HHS R35 GM127020
6 · The paper itself

Abstract

HP1s are involved in the assembly of heterochromatin and transcriptional regulation. Here, we report the molecular mechanisms underlying binding of the chromoshadow domain of HP1γ (HP1γ

Indexed as

Chromosomal Proteins, Non-HistoneMouse Embryonic Stem CellsRNA, Long NoncodingTripartite Motif-Containing Protein 28AnimalsChromobox Protein Homolog 5HumansMiceProtein BindingProtein MultimerizationChromobox Protein Homolog 5Chromosomal Proteins, Non-HistoneRNA, Long NoncodingTrim28 protein, mouseTripartite Motif-Containing Protein 28CP: molecular biologyCP: stem cell researchCSD domainHP1KAP1lncRNAmechanismstructure

Identifiers

PMID41575850
PMCPMC13021124

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.