Evidence map›Paper›PMID 41575879›Full record

ArticleChemistry & biodiversity2026

Synthesis, Characterization, Density Functional Theory Calculation, In Silico and In Vitro Antimicrobial Evaluation of New 1,2,4-Triazole-Amide Conjugates.

Fatima Zohra Nouayti, Khaoula Faiz, Yassine Rhazi, Fatimazahra Guerguer, Aziz Arzine, Bouchra Louasté, Samir Chtita, Mohammed Chalkha, Mohamed El Yazidi, Fatima Lazrak

Abstract read
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In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fatima Zohra NouaytiLaboratory of Medicinal Chemistry, Drug Sciences Research Center, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat, Morocco.
Khaoula FaizLaboratory of Biotechnology, Environment, Agri-food and Health, Faculty of Sciences Dhar El Mehraz, Sidi Mohamed Ben Abdellah University in Fez, Fez, Morocco.
Yassine RhaziLaboratory of Engineering of Organometallic, Molecular Materials, Environment, and Innovative Pedagogy, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University in Fez, Fez, Morocco.
Fatimazahra GuerguerLaboratory of Analytical and Molecular Chemistry, Faculty of Sciences Ben M'Sik, Hassan II University of Casablanca, Casablanca, Morocco.
Aziz ArzineLaboratory of Engineering of Organometallic, Molecular Materials, Environment, and Innovative Pedagogy, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University in Fez, Fez, Morocco.
Bouchra LouastéLaboratory of Biotechnology, Environment, Agri-food and Health, Faculty of Sciences Dhar El Mehraz, Sidi Mohamed Ben Abdellah University in Fez, Fez, Morocco.
Samir ChtitaLaboratory of Analytical and Molecular Chemistry, Faculty of Sciences Ben M'Sik, Hassan II University of Casablanca, Casablanca, Morocco.
Mohammed ChalkhaLaboratory of Engineering of Organometallic, Molecular Materials, Environment, and Innovative Pedagogy, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University in Fez, Fez, Morocco.ORCID https://orcid.org/0000-0002-9400-2183
Mohamed El YazidiLaboratory of Engineering of Organometallic, Molecular Materials, Environment, and Innovative Pedagogy, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University in Fez, Fez, Morocco.
Fatima LazrakLaboratory of Medicinal Chemistry, Drug Sciences Research Center, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat, Morocco.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present work describes the synthesis of new 1,2,4-triazole derivatives incorporating an amide moiety, obtained through a reaction sequence involving amidation, cyclization, and alkylation steps. Structural characterization of the synthesized 1,2,4-triazole-amide conjugates was confirmed by nuclear magnetic resonance (

Indexed as

AmidesAntifungal AgentsTriazolesAspergillus flavusCandida albicansFusariumMicrobial Sensitivity TestsMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructureSterol 14-DemethylaseStructure-Activity Relationship1,2,4-triazoleAmidesAntifungal AgentsSterol 14-DemethylaseTriazoles1,2,4‐triazoleamideantimicrobial activitydocking studiesMD stimulationsynthesis

Identifiers

PMID41575879
PMCPMC13420824

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.