ArticlePLoS biology2026
The conserved outer mitochondrial membrane protein Mtch regulates mitophagy during Drosophila intestinal development.
Article in PLoS biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The clearance of mitochondria by autophagy (mitophagy) is important for cell health. Mutations in genes that are required for mitophagy, including Vps13D, PINK1, and Parkin, are associated with movement disorders, but gaps exist in our understanding of how Vps13D regulates mitophagy. Here, we identify Mtch (MTCH2 in humans) as a regulator of mitophagy based on a relationship with Vps13D during developmentally programmed mitophagy in Drosophila intestine enterocyte cells. Similar to Vps13D mutant cells, Mtch mutant cells fail to clear mitochondria and possess elevated markers of autophagy. Genetic and molecular experiments reveal that Mtch and Vps13D function in a mitophagy pathway with PINK1, Parkin, and the mitophagy receptor BNIP3. Unlike Vps13D and Parkin mutant cells, Mtch is required for proper expression of the tail-anchored protein BNIP3. Thus, the tail-anchored protein insertase function of Mtch/MTCH2 likely explains how these proteins possess multiple cell context-specific functions.
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