Evidence map›Paper›PMID 41576154›Full record

ArticleScience advances2026

TDRD3, a Tudor domain-containing protein, regulates

Yun Shi, Xiaoqun Tao, Lei Shen, Yate-Ching Yuan, Guanpeng Wang, Ethan Eurmsirilerd, Rendell Chang, Zhenyu Jia, Weirong Shang, Yanzhong Yang and 1 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Maternal Krüppel-like factor 2 (KLF2)+ CD4 T cells promote fertility and fetal tolerance.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yun ShiDepartment of Immunology & Theranostics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.ORCID 0000-0002-4114-3388
Xiaoqun TaoDepartment of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope Cancer Center, Duarte, CA 91010, USA.ORCID 0009-0005-7950-001X
Lei ShenDepartment of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope Cancer Center, Duarte, CA 91010, USA.
Yate-Ching YuanTranslational Bioinformatics, Department of Computational Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.ORCID 0000-0002-3698-9784
Guanpeng WangDepartment of Immunology & Theranostics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.ORCID 0009-0004-3547-4844
Ethan EurmsirilerdDepartment of Botany & Plant Sciences, University of California, Riverside, CA 92527, USA.ORCID 0009-0009-3616-0237
Rendell ChangDepartment of Botany & Plant Sciences, University of California, Riverside, CA 92527, USA.ORCID 0009-0009-9326-1034
Zhenyu JiaDepartment of Botany & Plant Sciences, University of California, Riverside, CA 92527, USA.ORCID 0000-0002-1428-904X
Weirong ShangDepartment of Gynecology and Obsterics, School of Medicine, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0002-7993-9138
Yanzhong YangDepartment of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope Cancer Center, Duarte, CA 91010, USA.ORCID 0000-0002-1937-4526
Zuoming SunDepartment of Immunology & Theranostics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.ORCID 0000-0003-1896-6666

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARION Xenofon CHATZIIOANNOU · 1985 to 2026
$134.5M
Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI Victoria L. Seewaldt · 1985 to 2026
$86.3M
Steroid nuclear receptor coactivators in T cell differentiationR01AI109644 · NIAID · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Zuoming Sun · 2014 to 2026
$6.9M
NCI NIH HHS P30 CA016042NCI NIH HHS P30 CA033572NIAID NIH HHS R01 AI109644
6 · The paper itself

Abstract

Tudor domain-containing protein 3 (TDRD3) functions as a methylarginine reader that relays posttranslational arginine methylation signals to the transcriptional machinery, thereby regulating cellular functions through modulation of gene expression. Regulatory T cells (T

Indexed as

Cell DifferentiationImmune ToleranceKruppel-Like Transcription FactorsT-Lymphocytes, RegulatoryAnimalsColitisForkhead Box Protein O1Gene Expression RegulationMiceMice, KnockoutForkhead Box Protein O1Klf2 protein, mouseKruppel-Like Transcription Factors

Identifiers

PMID41576154
PMCPMC12829583

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.