ArticleThe Journal of allergy and clinical immunology2026
Platelet-macrophage cooperation drives IL-33-dependent type 2 lung immunopathology in a sex-biased manner.
Article in The Journal of allergy and clinical immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
15 authors.
Funding
Abstract
backgroundPlatelets amplify lung type 2 inflammation (T2I), but the underlying mechanisms remain incompletely understood.
objectiveWe elucidated the platelet-driven T2I mechanisms, particularly the role of platelet-derived leukotriene C
methodsWe assessed lung T2I to Alternaria alternata extract in vivo using mice with targeted deletions of Ltc4s in platelets, macrophages (Macs), or mast cells (MCs); Il33 in Macs, hematopoietic cells, or alveolar type 2 (AT2) cells; and cysteinyl leukotriene receptors. Exogenous administration of LTC
resultsPlatelets promoted IL-33 expression in perivascular Macs and induced transcellular LTC
conclusionAdherent platelets rapidly upregulate IL-33-expressing Macs, and platelet-derived LTC
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Registered trials
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