Evidence map›Paper›PMID 41577446›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2026

Alzheimer's Disease Pathologies Affect Dopaminergic Neural Mechanisms of Memory.

Thomas M Morin, Jordyn L Cowan, Hsiang-Yu Chen, Jourdan H Parent, Jennifer L Crawford, Claire J Ciampa, Vyoma D Shah, Ming Hsu, William J Jagust, Anne S Berry

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Thomas M MorinDepartment of Psychology, Brandeis University, Waltham, Massachusetts 02454.ORCID 0000-0003-4120-0669
Jordyn L CowanDepartment of Psychology, Brandeis University, Waltham, Massachusetts 02454.
Hsiang-Yu ChenDepartment of Psychology, Brandeis University, Waltham, Massachusetts 02454.ORCID 0000-0003-2531-536X
Jourdan H ParentDepartment of Psychology, Brandeis University, Waltham, Massachusetts 02454.
Jennifer L CrawfordDepartment of Psychology, Brandeis University, Waltham, Massachusetts 02454.ORCID 0000-0001-6392-361X
Claire J CiampaDepartment of Psychology, Brandeis University, Waltham, Massachusetts 02454.
Vyoma D ShahDepartment of Neuroscience, University of California Berkeley, Berkeley, California 94720.
Ming HsuHaas School of Business, University of California Berkeley, Berkeley, California 94720.ORCID 0000-0001-7195-3579
William J JagustDepartment of Neuroscience, University of California Berkeley, Berkeley, California 94720.ORCID 0000-0002-4458-113X
Anne S BerryDepartment of Psychology, Brandeis University, Waltham, Massachusetts 02454 anneberry@brandeis.edu.

Funding

Neural and Biochemical Mechanisms of Cognitive AgingR01AG034570 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI William J. Jagust · 2009 to 2026
$12.0M
Upregulated Norepinephrine Synthesis Capacity in AgingR01AG074330 · NIA · BRANDEIS UNIVERSITY · PI Anne Shively Berry · 2022 to 2026
$6.2M
Mechanisms of Alzheimer's Disease Progression in the Aging BrainR01AG062542 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI JAGUST, WILLIAM J. · 2019 to 2023
$4.2M
Aging Brain, Cognition, and DopamineR01AG044292 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI JAGUST, WILLIAM J. · 2013 to 2017
$3.6M
Age effects on memory and reward systems in decision makingR00AG058748 · NIA · BRANDEIS UNIVERSITY · PI BERRY, ANNE SHIVELY · 2019 to 2021
$745k
Age effects on memory and reward systems in decision makingK99AG058748 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI BERRY, ANNE SHIVELY · 2018 to 2019
$250k
Conjoint Effects of Dopamine and Tau on Cognition in AgingF32AG084259 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Thomas Morin · 2024 to 2026
$247k
Neurobiological mechanisms of daily life activity participation in older adultsF32AG085890 · NIA · BRANDEIS UNIVERSITY · PI CRAWFORD, JENNIFER L. · 2024 to 2025
$129k
NIA NIH HHS F32 AG084259NIA NIH HHS F32 AG085890NIA NIH HHS K99 AG058748NIA NIH HHS L30 AG089518NIA NIH HHS R00 AG058748NIA NIH HHS R01 AG034570NIA NIH HHS R01 AG044292NIA NIH HHS R01 AG062542NIA NIH HHS R01 AG074330
6 · The paper itself

Abstract

Aging is accompanied by the disruption of multiple neural systems including alteration in dopamine neurotransmission as well as through the accumulation of neuropathology. Despite broad appreciation that complex mental function relies on integration across systems, there is a general lack of understanding of how multiple age- and disease-related brain features interact to drive variation in performance. To address this gap, we used positron emission tomography in male and female humans to examine independent and combined impacts of dopamine synthesis capacity ([

Indexed as

Alzheimer DiseaseBrainDopamineMemoryAdultAgedAged, 80 and overAgingFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPositron-Emission TomographyYoung AdultDopamineAlzheimer’s diseasedopaminefMRImemoryPETreward

Identifiers

PMID41577446
PMCPMC12925676

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.