ArticleNPJ breast cancer2026
Racial differences in biomarkers, treatment, and outcomes in HR+/HER2- metastatic breast cancer in the United States.
Article in NPJ breast cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
This study examined biomarker alteration prevalence, treatment patterns, and clinical outcomes among patients with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer to investigate racial differences. Analysis of 2,384 patients from the Flatiron Health-Foundation Medicine clinico-genomic database (FH-FMI CGDB) (2017-2022) assessed PIK3CA, AKT1, PTEN, ESR1, and BRCA1/2 alterations via NGS testing. Treatment patterns and overall survival were evaluated. In the study population (13% Black, 87% White), Black patients had lower PIK3CA mutation rates (34% vs. 42%, p = 0.03). In first-line treatment, Black patients were less likely to receive CDK4/6 inhibitors (53% vs. 66%, p < 0.01) and more likely to receive chemotherapy (27% vs. 17%, p < 0.01). After adjustment, Black patients had 38% lower odds of receiving first-line CDK4/6 inhibitors and experienced significantly shorter median overall survival (34.1 vs. 42.1 months, p < 0.01). Significant differences exist in biomarker prevalence, treatment access, and survival outcomes in HR+/HER2- metastatic breast cancer by race, highlighting unmet medical needs.
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Registered trials
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