SynthesisMolecular neurobiology2026
Exploring Green-Synthesized Silver Nanoparticles in Neurodegeneration: a Systematic Review of Cholinesterase Enzyme Interactions.
Synthesis in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
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Abstract
Neurodegenerative disorders, particularly Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD), represent a significant and growing global health concern in recent decades due to their complex pathology and lack of curative treatments. The fundamental cause of the evolution of these disorders is the dysfunction of cholinergic neurotransmission; those are mostly regulated by cholinesterase enzymes such as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Conventional synthetic cholinesterase inhibitors like donepezil, rivastigmine, and galantamine are proposed for symptomatic relief but are often associated with adverse effects, limited bioavailability, and decreased long-term efficacy. Here, green-synthesized silver nanoparticles (AgNPs), which are derived from plant extracts and other biological systems, give an extraordinary alternative. These nanoparticles offer a biocompatible, eco-friendly, and cost-effective alternative to conventional synthetic methods. Greener AgNPs inhibit them by binding to the enzymes AChE and BChE and prevents them from breaking down neurotransmitters ACh and BCh. As a result, the count of neurotransmitters remains high in the synapse and can provide an effective synaptic transmission. Green-synthesized AgNPs can provide targeted drug delivery, enhance solubility, enhance bioavailability, improve absorption, and also be able to overcome the blood-brain barrier (BBB); all these characteristics give better therapeutic action than all conventional methods. This study evaluates the efficacy of green-synthesized silver nanoparticles in combination with several medicinal plants for treating neurodegenerative diseases, encouraging further research to upgrade these formulations for improved patient outcomes and increased clinical applicability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.