ArticleAdvances in experimental medicine and biology2026
Cerebral Edema Depends on the Results of Large Vascular Occlusion Reperfusion Therapy.
Article in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
The objective was to quantify the effect of endovascular therapy (EVT) results of large-vessel occlusion (LVO) on brain tissue hydration, assessed by net water uptake (NWU). MATERIALS AND
methodsNinety-three patients with EVT of acute ischemic stroke (AIS) due to acute LVO (men-44, women-49, median age 68.7) were included in this retrospective, non-randomized, single-center study. EVT was performed under general anesthesia with approved devices, including a stent retriever and aspiration catheters. Net water uptake (NWU) in ischemic zones was evaluated using non-contrasted computed tomography (CT). NWU was calculated using the well-known formula in the symmetrical zone of the brain, in admission and follow-up non-contrasted CT scans, 24 h after EVT.
resultsFifty-seven patients had successful arterial recanalization (Thrombolysis in Cerebral Infarction scale [TICI] 2b-3), while 36 patients had persistent or recurrent acute LVO (TICI 0-2a). The NWU median at admission was 3.4% in patients with successful EVT and 5.1% in patients with unsuccessful EVT (p < 0.05). The follow-up NWU median was 7.2% after successful EVT and 12.8% in patients with persistent/recurrent acute LVO (p < 0.001).
conclusionSuccessful arterial recanalization at AIS due to LVO (TICI 2b -3) led to a significant reduction in brain edema progression in cerebral ischemic foci.
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