Evidence map›Paper›PMID 41578026›Full record

ArticleNeurochemical research2026

Metformin Ameliorates Cognitive Deficits and Neuroinflammation in a Mouse Model of Familial Hypercholesterolemia.

Natália Baltazar do Nascimento, Hémelin Resende Farias, Tainá Schons, Alex Paulo Zeferino Padilha, Mariana Viana Costa, Ariadni Mesquita Peres, Lucas Dos Santos da Silva, Ricardo Maia Dantas, Jessica Marques Obelar Ramos, Matheus Scarpatto Rodrigues and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurochemical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Natália Baltazar do NascimentoDepartment of Biochemistry, Basic Health Sciences Institute, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.ORCID http://orcid.org/0000-0001-6820-7452
Hémelin Resende FariasDepartment of Biochemistry, Basic Health Sciences Institute, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.ORCID http://orcid.org/0000-0003-4918-4982
Tainá SchonsDepartment of Biochemistry, Basic Health Sciences Institute, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.ORCID http://orcid.org/0000-0001-8330-3485
Alex Paulo Zeferino PadilhaDepartment of Biochemistry, Basic Health Sciences Institute, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.ORCID http://orcid.org/0009-0003-5068-9299
Mariana Viana CostaDepartment of Biochemistry, Basic Health Sciences Institute, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.ORCID http://orcid.org/0009-0008-2455-9833
Ariadni Mesquita PeresDepartment of Biochemistry, Basic Health Sciences Institute, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.ORCID http://orcid.org/0000-0002-1987-3261
Lucas Dos Santos da SilvaDepartment of Biochemistry, Basic Health Sciences Institute, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.ORCID http://orcid.org/0000-0001-8296-0248
Ricardo Maia DantasDepartment of Biochemistry, Basic Health Sciences Institute, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.ORCID http://orcid.org/0000-0003-0590-8221
Jessica Marques Obelar RamosDepartment of Biochemistry, Basic Health Sciences Institute, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.ORCID http://orcid.org/0000-0003-1213-4519
Matheus Scarpatto RodriguesDepartment of Biochemistry, Basic Health Sciences Institute, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.ORCID http://orcid.org/0000-0002-7794-6588
Fernanda TellesDepartment of Biochemistry, Basic Health Sciences Institute, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.ORCID http://orcid.org/0000-0003-0360-2747
Fátima Theresinha Costa Rodrigues GumaDepartment of Biochemistry, Basic Health Sciences Institute, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.ORCID http://orcid.org/0000-0003-2369-7739
José Cláudio Fonseca MoreiraDepartment of Biochemistry, Basic Health Sciences Institute, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.ORCID http://orcid.org/0000-0002-0619-4913
Rachel Krolow Santos Silva BastDepartment of Biochemistry, Basic Health Sciences Institute, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.ORCID http://orcid.org/0000-0001-6217-1647
Andreza Fabro de BemLaboratory of Bioenergetics and Metabolism, University of Brasília, Brasilia, Federal District, Brazil.ORCID http://orcid.org/0000-0003-1090-5244
Jade de OliveiraDepartment of Biochemistry, Basic Health Sciences Institute, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil. deoliveirajade10@gmail.com.ORCID http://orcid.org/0000-0003-1454-2866

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Familial hypercholesterolemia (FH), caused by mutations in the low-density lipoprotein receptor (LDLr) gene, has been increasingly associated with neurodegenerative and mood disorders. Studies with LDLR knockout mice (LDLr

Indexed as

Cognitive DysfunctionHyperlipoproteinemia Type IIMetforminNeuroinflammatory DiseasesAnimalsAstrocytesDisease Models, AnimalHippocampusMaleMiceMice, Inbred C57BLMice, KnockoutMicrogliaReceptors, LDLMetforminReceptors, LDLAstrocytesBehavioral alterationsFamilial hypercholesterolemiaLDLr−/− miceMetformin

Identifiers

PMID41578026
PMCPMC12830493

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.