Observational studyJournal of general internal medicine2026
Gender Differences in Statin Discontinuation and Adherence Among Privately Insured People with HIV in the USA.
Observational study in Journal of general internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
12 authors.
Funding
Abstract
backgroundPeople with HIV (PWH), particularly women, have a high cardiovascular disease (CVD) burden compared to the general population. There is little evidence describing statin adherence among PWH, which could inform interventions to reduce CVD disparities.
objectiveObservational cohort of privately insured PWH under age 65 who initiated statin therapy during 2015-2022 in MarketScan data. MAIN MEASURES: We used outpatient pharmacy claims to examine (1) statin discontinuation, defined as a gap > 90 days, and (2) proportion of days covered (PDC) by a statin in 90-day intervals. We estimated hazard ratios (HRs) using Cox models to compare discontinuation rates and prevalence ratios (PRs) from log-binomial regression to compare the probability of having low adherence (PDC < 80%) between women and men. We adjusted for potential confounding by demographic and clinical factors and accounted for repeated PDC measures. KEY
resultsWe included 9522 PWH who initiated a statin (median age 52 years, 17.3% women). Overall, 50.0% of PWH had statin discontinuation within 2 years, and 26.5% had low adherence during statin therapy. Within 2 years, 59.0% of women and 48.1% of men had experienced discontinuation (adjusted HR 1.30 (95% CI, 1.20-1.41)). Among PWH remaining on statins, low adherence (PDC < 80%) was more common among women (34.1%) than men (25.2%) (adjusted PR 1.29 (1.22-1.35)).
conclusionsPWH had high statin discontinuation rates, and a quarter had low adherence. Compared to men, women were both more likely to discontinue and have lower adherence. Efforts are needed to address statin adherence barriers to prevent CVD in PWH, especially in women with HIV.
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