ArticleBMC genomics2026
Multi-omics analyses of Dracocephalum moldavica L. reveal two flavonoid glycosyltransferases in tilianin biosynthesis.
Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Phytochemical Diversity and Antioxidant Potential ofAntioxidants (Basel, Switzerland) · 2026Review
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5 authors.
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Abstract
backgroundTo explore reference genome of Dracocephalum moldavica L. and provide a basis for the study of the mechanism of tilianin biosynthesis.
resultsWe present telomere-to-telomere (T2T) genome assembly with the size of 255.61 Mb and a contig N50 length of 58.45 Mb. By integrating multi-omics resources, we identified two UDP- glycosyltransferases, Dm7GlcT1 and Dm7GlcT2, catalyzing the glucosylation of acacetin at 7-OH, which was the final step in tilianin biosynthetic pathway. The findings from the in vitro enzyme activity assay and qRT-PCR analysis further indicate that Dm7GlcT1 may be responsible for catalyzing tilianin biosynthesis in stems and flowers, whereas glucosylation mediated by Dm7GlcT2 could occur in all tissues.
conclusionOur work presents the first T2T genome assembly of D. moldavica and identified two key UDP- glycosyltransferases associated with tilianin biosynthesis, which provided a valuable reference for further metabolic network construction of tilianin biosynthesis and genetic improvement of D. moldavica with high tilianin product.
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