Evidence map›Paper›PMID 41578197›Full record

ArticleBMC cardiovascular disorders2026

Domestic water hardness, genetic susceptibility, and risk of symptomatic abdominal aortic aneurysm: a cohort study of UK biobank.

Chenshu Li, Qun Huang, Kailang Liu, Xinggang Wang, Peng Qiu, Ruihua Wang

Abstract read
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Article in BMC cardiovascular disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chenshu Li *Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, 639 Zhizaoju Rd, Shanghai, 200011, China.
Qun Huang *Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, 639 Zhizaoju Rd, Shanghai, 200011, China.
Kailang Liu *Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, 639 Zhizaoju Rd, Shanghai, 200011, China.
Xinggang WangDepartment of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, 639 Zhizaoju Rd, Shanghai, 200011, China. xinggang.wang@hotmail.com.
Peng QiuDepartment of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, 639 Zhizaoju Rd, Shanghai, 200011, China. hiiigh4@gmail.com.
Ruihua WangDepartment of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, 639 Zhizaoju Rd, Shanghai, 200011, China. wangruihua@sjtu.edu.cn.

Funding

Clinical Research Program of the 9th People's Hospital JYLJ202010Health Research Project of Anhui Province AHWJ2024Aa20284,AHWJ2022A031National Natural Science Foundation of China 82170411, 82300540, 82170509, 82370494Rare Disease Biobank Registration and Registry Project JYHJB202404Shanghai Ninth People's Hospital Medical-Enterprise Integration Laboratory Project YQRH202501Shanghai Science and Technology Innovation Action Plan 20Y11909600Shanghai STC Innovative Medical Product Application Demonstration Project 25SF1905004,25SF1905000,25SF1904800,25SF1905100
6 · The paper itself

Abstract

objectiveThis study aimed to investigate the relationship between domestic water hardness and risk of symptomatic abdominal aortic aneurysm (AAA) and explore whether this association was modified by genetic predisposition to AAA.

methodsExposures of interest included concentration of calcium (Ca), magnesium (Mg), calcium carbonate (CaCO

resultsThis study included 371,668 participants. Over a median follow-up duration of 15.2 years, 2,154 new cases of symptomatic AAA were recorded. A negative association was observed between exposure to Ca and CaCO

conclusionOur study found that exposure to domestic hard water was associated with a reduced risk of symptomatic AAA, regardless of individuals ' genetic risk. These findings reinforce the recommendations on the importance of maintaining and supplementing minerals in drinking water, such as using filtered or desalinated water.

Indexed as

Aortic Aneurysm, AbdominalDrinking WaterAgedCalciumCalcium CarbonateFemaleGenetic Predisposition to DiseaseGenetic Risk ScoreHardnessHumansMagnesiumMaleMiddle AgedPhenotypeProtective FactorsRisk AssessmentCalciumCalcium CarbonateDrinking WaterMagnesiumAbdominal aortic aneurysmDomestic water hardnessGenetic susceptibilityMineralRisk factor

Identifiers

PMID41578197
PMCPMC12911312

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.