Evidence map›Paper›PMID 41578277›Full record

ArticleBMC medicine2026

Association of short-term exposure to ambient air pollutants with liver function and mediation by fasting insulin: evidence from a rural cohort in China.

Mengxin Wang, Aogang Zhang, Shuaiqi Zhao, Yuling Zeng, Han Sun, Qiong Wu, Jiayin Li, Yue Du, Yuxuan Chai, Jie Song and 3 more

Abstract read
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In one paragraph

Article in BMC medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mengxin WangHenan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, China.
Aogang ZhangHenan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, China.
Shuaiqi ZhaoHenan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, China.
Yuling ZengHenan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, China.
Han SunHenan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, China.
Qiong WuHenan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, China.
Jiayin LiHenan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, China.
Yue DuHenan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, China.
Yuxuan ChaiHenan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, China.
Jie SongHenan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, China.
Laibao ZhuoHenan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, China.
Hui WuHenan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, China.
Weidong WuHenan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, 453003, China. Wdwu2013@126.com.

Funding

National Key Research and Development Program of China 2016YFC0900803
6 · The paper itself

Abstract

backgroundAir pollution and the rising prevalence of liver diseases have become public health concerns. Nevertheless, the relationship and underlying mechanisms between ambient air pollution and liver function remain inadequately investigated.

methodsA total of 4096 rural residents living in the suburb of Xinxiang city, China, were recruited from the Henan Rural Cohort. The participants underwent two physical examinations conducted in 2017 and 2021, respectively. A linear mixed-effects model was utilized to evaluate the associations between individual ambient air pollutants and liver function biomarkers. To determine the main air pollutants that impact liver function biomarkers, weighted quantile sum (WQS) regression models were applied. Additionally, the mediating role of fasting insulin (FINS) in these associations was investigated using mediation analysis.

resultsFor each increase in the interquartile range (IQR) of fine particulate matter (PM

conclusionsThere is a positive association between short-term exposure to ambient air pollutants and biomarkers of liver function. Moreover, FINS may play mediating roles in these associations.

Indexed as

Air PollutantsAir PollutionEnvironmental ExposureInsulinLiverAdultBiomarkersChinaCohort StudiesFastingFemaleHumansLiver Function TestsMaleMiddle AgedParticulate MatterAir PollutantsBiomarkersInsulinParticulate MatterAir pollutionFasting insulinLiver functionMediation

Identifiers

PMID41578277
PMCPMC12911160

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.