Evidence map›Paper›PMID 41578354›Full record

ArticleItalian journal of pediatrics2026

Cord blood cardiac markers and tissue doppler echocardiography findings in infants of diabetic mothers.

Sema Nur Taşkın, Vehbi Doğan, Zeynep Kasap Acungil, Rüveyda Gümüşer Cinni, Serap Bilge, Şeyma Ünüvar Gök, Leyla Aydoğan, İsmail Benli, Arzu Er Kara, Deniz Anuk İnce and 1 more

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Article in Italian journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Sema Nur TaşkınDepartment of Pediatrics, Faculty of Medicine, Tokat Gaziosmanpaşa University, Tokat, Türkiye. sntistanbul@gmail.com.ORCID http://orcid.org/0000-0003-3400-1514
Vehbi DoğanDivision of Pediatric Cardiology, Department of Pediatrics, Faculty of Medicine, Tokat Gaziosmanpaşa University, Tokat, Türkiye.
Zeynep Kasap AcungilDepartment of Physiotherapy and Rehabilitation, Faculty of Health Science, Tokat Gaziosmanpasa University, Tokat, Türkiye.
Rüveyda Gümüşer CinniDepartment of Pediatrics, Faculty of Medicine, Tokat Gaziosmanpaşa University, Tokat, Türkiye.
Serap BilgeDepartment of Pediatrics, Faculty of Medicine, Tokat Gaziosmanpaşa University, Tokat, Türkiye.
Şeyma Ünüvar GökDepartment of Pediatrics, Faculty of Medicine, Tokat Gaziosmanpaşa University, Tokat, Türkiye.
Leyla AydoğanDepartment of Pharmaceutics Services, Tokat Vocational School of Health Services, Gaziosmanpasa University, Tokat, Türkiye.
İsmail BenliDepartment of Pharmaceutics Services, Tokat Vocational School of Health Services, Gaziosmanpasa University, Tokat, Türkiye.
Arzu Er KaraDepartment of Cardiology, Tokat State Hospital, Tokat, Türkiye.
Deniz Anuk İnceDivision of Neonatology, Department of Pediatrics, Faculty of Medicine, Tokat Gaziosmanpaşa University, Tokat, Türkiye.
Resul YılmazDepartment of Pediatrics, Faculty of Medicine, Tokat Gaziosmanpaşa University, Tokat, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMaternal diabetes mellitus (DM) significantly affects fetal cardiac and placental structure and function. This study aimed to assess structural and functional cardiac changes in infants of diabetic mothers (IDMs) using echocardiographic data and cord blood cardiac biomarkers.

methodsM-mode and pulsed-wave tissue Doppler imaging (PW-TDI) echocardiography along with cord blood cardiac markers were evaluated in 40 IDMs and 40 healthy term newborns. Cardiac biomarkers included troponin T (Trop-T), N-terminal pro-brain natriuretic peptide (NT-proBNP), and ischemia-modified albumin (IMA).

resultsAmong the diabetic mothers, 87.5% had gestational diabetes mellitus (GDM) and 12.5% had type 1 diabetes mellitus (T1DM). Interventricular septum (IVS) thickness was significantly greater in the IDM group. Of the IDMs, 32.5% had asymmetric septal hypertrophy. Mid-septal tissue Doppler Imaging (TDI) parameters showed significantly altered velocities and time intervals. NT-proBNP and IMA levels were significantly elevated in the IDMs group, while Trop-T was not statistically different. No correlation was found between TDI parameters and biomarker levels.

conclusionCardiac dysfunction and elevated cord blood biomarkers in IDMs reflect subclinical stress. These findings support the utility of TDI and biochemical markers for early cardiac assessment in IDMs. Larger studies are needed to validate the use of these markers for routine screening and to better understand their pathophysiological significance.

Indexed as

Diabetes, GestationalEchocardiography, DopplerFetal BloodNatriuretic Peptide, BrainPregnancy in DiabeticsAdultBiomarkersCase-Control StudiesFemaleHumansInfant, NewbornMalePeptide FragmentsPregnancySerum Albumin, HumanTroponin TBiomarkersischemia-modified albuminNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Serum Albumin, HumanTroponin TCardiac biomarkersInfant of diabetic mothers (IDMs)Ischemia-modified albumin (IMA)N-terminal pro-brain natriuretic peptide (NT-proBNP)Tissue doppler imaging (TDI)Troponin T (Trop-T)

Identifiers

PMID41578354
PMCPMC12911013

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.