ArticleMagnetic resonance in medicine2026
Reproducibility of QQ (QSM + qBOLD) Oxygen Extraction Fraction (OEF) Mapping in the Brain at 3 and 1.5 T.
Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThis study aims to assess the repeatability and reproducibility of qBOLD+QSM (QQ) oxygen extraction fraction (OEF) measurements across 3 and 1.5 T.
methodsThe effects of field strength on signal to noise ratio (SNR) and OEF sampling time were experimentally assessed in 14 healthy subjects using repeated scans performed at 3 and 1.5 T. Whole-brain and regional OEF values were analyzed using Bland-Altman and correlation between repeated scans and across field strengths.
resultsWhole-brain and regional OEF values showed strong agreement between repeated scans at the same field strength, with minimal differences (≤ 0.74%) and high correlation (r > 0.92). Across field strengths, comparisons similarly showed small mean differences (≤ 1.51%) and strong correlations (r > 0.95).
conclusionQQ-OEF has good repeatability and reproducibility at both 3 and 1.5 T. Good performance at 1.5 T may arise from accurate noise modeling and longer sampling times at lower field strengths.
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