ArticleNeurogastroenterology and motility2026
Exploring Clinical Similarities and Distinctions Between Gastroparesis and Functional Dyspepsia: A Propensity-Matched Cohort Study.
Article in Neurogastroenterology and motility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Exploring Clinical Similarities and Distinctions Between Gastroparesis and Functional Dyspepsia: A Propensity-Matched Cohort Study.Neurogastroenterology and motility · 2026Article
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8 authors.
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Abstract
BACKGROUND AND
aimsGastroparesis and functional dyspepsia often share overlapping upper gastrointestinal symptoms but may differ in symptom patterns, treatment, and health care utilization. We assessed their clinical similarities and distinctions in the largest national cohort study to date.
methodsWe performed a retrospective cohort study using the TriNetX database, identifying patients through administrative codes. Individuals with structural gastric or small bowel abnormalities or prior gastric surgery were excluded. Gastroparesis required a diagnosis within three months of a gastric emptying study, at least one typical symptom, and an upper endoscopy within 12 months prior. Functional dyspepsia required a diagnosis with prior endoscopy (1-12 months) and symptoms 6-12 months before diagnosis. Primary outcomes were medication use and healthcare utilization; secondary outcomes included symptom burden and coexisting disorders of gut-brain interaction. Propensity score matching (1:1) adjusted for demographics and comorbidities. Relative risks with 95% confidence intervals were calculated.
resultsWe identified 2488 patients with gastroparesis and 3676 with functional dyspepsia; after matching, 1914 per group remained. Gastroparesis showed greater use of prokinetics (52.7% vs. 19.6%; p < 0.0001) and antiemetics, and higher rates of endoscopy (41.4% vs. 21.2%), emergency visits (45.3% vs. 40.2%), and hospitalization (28.2% vs. 21.6%) (all p < 0.01). Nausea, vomiting, and distension were more frequent in gastroparesis, while epigastric pain predominated in functional dyspepsia (p < 0.0001).
conclusionGastroparesis and functional dyspepsia show distinct symptom distributions and treatment patterns, with higher health care utilization in gastroparesis, supporting mechanism-based individualized management.
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