Evidence map›Paper›PMID 41578665›Full record

ReviewComprehensive Physiology2026

Hypercapnia Effects on Lung Function.

Seungseo Choi, Laura A Dada, Jacob I Sznajder

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Comprehensive Physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Hypercapnia Effects on Lung Function.Comprehensive Physiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Seungseo ChoiDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Laura A DadaDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Jacob I SznajderDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

Funding

NIH HHS NHLBI-RO1 HL173987
6 · The paper itself

Abstract

The biological effects of hypercapnia on the lungs have been controversial. Earlier publications suggesting that hypercapnia was beneficial for mechanically ventilated patients with acute lung injury led to the clinical paradigm of "permissive hypercapnia". However, more recent studies have challenged this paradigm by reporting that hypercapnia activates signaling pathways with deleterious effects. This review focuses on the effects of elevated CO

Indexed as

HypercapniaLungAnimalsCarbon DioxideHumansSignal TransductionCarbon Dioxide

Identifiers

PMID41578665
PMCPMC12831041

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.