ArticleEuropean heart journal2026
Long forms of cardiac troponin T for myocardial infarction diagnosis: the SuperTROPO study.
Article in European heart journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Functional Autoantibodies in Myocardial Diseases.JACC. Basic to translational science · 2026Review
- Clinical Gray Zones of Cardiac Troponin Interpretation in the Emergency Department: When Increased Concentrations Do Not Equal Acute Coronary Syndrome.Journal of clinical medicine · 2026Review
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
BACKGROUND AND
aimsElevated cardiac troponin levels are a frequent finding in emergency department patients, often without a clear cause. Current high-sensitivity cardiac troponin T (cTnT) assays measure intact and fragmented cardiac troponin T (total cTnT) molecules, without distinguishing between them. This study investigated whether measuring only intact and minimally fragmented cTnT (long cTnT) provides additional value for myocardial infarction (MI) identification.
methodsConsecutive emergency department patients with standard high-sensitivity cTnT levels (Roche Diagnostics) above the upper reference limit (≥14 ng/L) were recruited. Long cTnT levels were measured using a novel immunoassay. The additional diagnostic value of long cTnT in identifying patients with type 1 MI or any MI was assessed.
resultsA total of 1811 patients participated in the study, 1145 (63.2%) presenting with chest pain or dyspnoea. Overall, 205 (11.3%) had MI, including 148 classified as type 1 MI. Only .7% of patients in the lowest long cTnT tertile (<3.7 ng/L) had type 1 MI. The discriminative ability of long cTnT was superior to total cTnT in identifying patients with MI (area under curve [95% confidence intervals]) for any MI: .833 (.804-.863) vs .782 (.744-.819), and for type 1 MI: .839 (.807-.872) vs .777 (.735-.819), both (P < .001). Integrating the predictive data from long cTnT with total cTnT provided additional value in both reclassification and decision curve analyses, compared to total cTnT data alone.
conclusionsThe long cTnT assay demonstrated good diagnostic performance in identifying MI in patients with elevated total cTnT levels, with the potential to improve the accuracy of MI diagnosis.
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