Evidence map›Paper›PMID 41579075›Full record

Trial reportJournal of the International Society of Sports Nutrition2025

Short-term creatine supplementation enhances strength, reduces fatigue, and accelerates recovery in resistance-trained athletes: a double-blind, randomized, crossover trial.

Atef Salem, Achraf Ammar, Mohamed Kerkeni, Mohamed Ali Boujelbane, Ayse Merve Uyar, Leonard Moritz Köbel, Saranya Selvaraj, Reza Zare, Katie M Heinrich, Haitham Jahrami and 5 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the International Society of Sports Nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Atef SalemDepartment of Training and Movement Science, Institute of Sport Science, Johannes Gutenberg-University Mainz, Mainz, Germany.ORCID 0000-0003-0680-6841
Achraf AmmarDepartment of Training and Movement Science, Institute of Sport Science, Johannes Gutenberg-University Mainz, Mainz, Germany.
Mohamed KerkeniHigh Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax, Tunisia.
Mohamed Ali BoujelbaneDepartment of Training and Movement Science, Institute of Sport Science, Johannes Gutenberg-University Mainz, Mainz, Germany.
Ayse Merve UyarDepartment of Training and Movement Science, Institute of Sport Science, Johannes Gutenberg-University Mainz, Mainz, Germany.
Leonard Moritz KöbelDepartment of Training and Movement Science, Institute of Sport Science, Johannes Gutenberg-University Mainz, Mainz, Germany.
Saranya SelvarajDepartment of Chemistry, Faculty of Applied Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri Lanka.
Reza ZareSRH Campus Hamburg, SRH University of Applied Sciences Heidelberg, Hamburg, Germany.
Katie M HeinrichDepartment of Kinesiology, Kansas State University, Manhattan, KS, USA.
Haitham JahramiGovernment Hospitals, Manama, Bahrain.
Slim TounsiLaboratory of Biopesticides (LBPES), Center of Biotechnology of Sfax, University of Sfax, Sfax, Tunisia.
Giuseppe GrossoDepartment of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
Wolfgang I SchöllhornDepartment of Training and Movement Science, Institute of Sport Science, Johannes Gutenberg-University Mainz, Mainz, Germany.
Khaled TrabelsiHigh Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax, Tunisia.
Hamdi ChtourouHigh Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhile the long-term ergogenic benefits of creatine monohydrate (CrM) supplementation are well-documented, the potential advantages of acute ingestion followed by short-term consumption remain relatively underexplored. This double-blind, randomized crossover study investigated the acute and short-term effects of CrM supplementation on strength performance, heart rate variability (HRV) responses, and recovery of lower limbs strength and muscle soreness in resistance-trained males.

methodsA total of eleven physically active participants were recruited; however, due to incomplete data, one participant was excluded, and ten participants (age: 21.3 ± 1.9 years) were analyzed. Participants ingested either creatine monohydrate (CrM: 0.3 g·kg

resultsCompared to PLA, CrM supplementation significantly increased repetitions completed at 60-80% 1RM in BP and BS (

conclusionThese findings demonstrate that even three days of CrM supplementation have the potential to enhance strength performance, reduce physiological stress, and accelerate recovery, suggesting it as an effective ergogenic strategy for athletes seeking immediate performance gains and reduced post-exercise soreness.

Indexed as

CreatineDietary SupplementsMuscle FatigueMuscle StrengthPerformance-Enhancing SubstancesResistance TrainingAdultAthletesAthletic PerformanceCross-Over StudiesDouble-Blind MethodHeart RateHumansMaleMyalgiaSports Nutritional Physiological PhenomenaCreatinePerformance-Enhancing SubstancesCreatineergogenic effectperformancerecoveryresistance exercise

Identifiers

PMID41579075
PMCPMC12833896

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.