ReviewCellular and molecular neurobiology2026
Mechanisms and Clinical Application Progress of Exercise in the Treatment of Neuropathic Pain.
Review in Cellular and molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Neuropathic Pain: Mapping the miRNA Landscape.Non-coding RNA · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Neuropathic pain has a complex pathogenesis and poses significant treatment challenges. In recent years, exercise has garnered increasing attention as a nonpharmacological intervention for the management of neuropathic pain. This review systematically examines the research progress on the neurobiological mechanisms of exercise in the treatment of neuropathic pain, including its effects on improving neuroinflammation, alleviating oxidative stress, modulating neuroplasticity, influencing the descending pain modulation system, and regulating gene expression and epigenetic modifications. Additionally, this review summarizes the application and therapeutic effects of various exercise interventions in different types of neuropathic pain, such as neuropathic pain after spinal cord injury, chemotherapy-induced peripheral neuropathy, diabetic peripheral neuropathy, and neuropathic pain in multiple sclerosis, on the basis of current clinical research. It also explores future research directions and trends in this field. By integrating basic research and clinical evidence, this review aims to provide a theoretical basis and practical guidance for exercise therapy in patients with neuropathic pain. Although existing evidence supports the analgesic potential of exercise, future high-quality clinical studies are needed to optimize individualized exercise prescriptions and further explore its molecular and neural circuit mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.