ReviewCurrent pain and headache reports2026
Neuroinflammation and Pediatric Chronic Pain - A Review.
Review in Current pain and headache reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Review
- Allergic diseases in early childhood and their association with migraine: a large-scale retrospective study.Frontiers in allergy · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewTo report on the relationship between neuroinflammation and chronic pain, especially in the pediatric population. Pediatric chronic pain is prevalent, affecting about 20% of the population. Neuroinflammation is now recognized as a putative contributing factor to the development and maintenance of chronic pain. Strides have been made in understanding neuroinflammatory processes in the context of pain, as research begins to unravel the involvement of glial cells (e.g., microglia, astrocytes), pro-inflammatory markers (e.g., interleukins, Tumor Necrosis Factor-alpha [TNF-α]), and metabolic pathways (e.g., oxidative stress). In children, the vulnerability of a developing nervous system, life stressors (e.g., adjustment periods/transitions, social stress, family dynamics) and hormonal changes can further impact neuroinflammation and promote pain. Investigating this complex web of factors that contribute to pediatric pain has implications for both clinical practice and research. This review aims to summarize recent literature on the role of neuroinflammation in pediatric chronic pain, highlighting novel insights and areas for future clinical exploration. Targeting neuroinflammation shows promise for advancing pediatric chronic pain management, but pediatric-specific studies remain quite limited, and urgently needed.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.