Evidence map›Paper›PMID 41580463›Full record

ArticleScientific reports2026

Efficient apoptosis via double-strand breaks of DNA in human epithelial cells induced by non-thermal effect of high-field broadband terahertz waves.

Huan Zhou, Xingyi Wei, Xiao-Yu Peng, Yangjiuzhou Gou, Zhang Yue, Julia Li Zhong, Jing Li, Cheng Zhang, Xi Zhang, De-Sheng Pei

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Huan ZhouChongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, 400714, China.
Xingyi WeiChongqing Medical University, Chongqing, 400016, China.
Xiao-Yu PengChongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, 400714, China. xypeng@cigit.ac.cn.
Yangjiuzhou GouChongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, 400714, China.
Zhang YueChongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, 400714, China.
Julia Li ZhongChongqing University, Chongqing, 400044, China.
Jing LiMedical Center of Hematology, Xinqiao Hospital, Army Medical University, Chongqing, 400000, China.
Cheng ZhangMedical Center of Hematology, Xinqiao Hospital, Army Medical University, Chongqing, 400000, China.
Xi ZhangMedical Center of Hematology, Xinqiao Hospital, Army Medical University, Chongqing, 400000, China.
De-Sheng PeiChongqing Medical University, Chongqing, 400016, China. peids@cqmu.edu.cn.

Funding

Chongqing Technology Innovation and Application Development: Sichuan-Chongqing Science and Technology Innovation Cooperation Program Project CSTB2024TIAD-CYKJCXX0017High-level Talents Project of Chongqing Medical University R4014NSAF Joint Fund U2030119
6 · The paper itself

Abstract

Induction of apoptosis is a primary strategy in cancer therapies in clinical oncology. Chemical or biological stimuli generally result in drug or agent resistance and damage to the immune system. Current physical stimuli have strong side effects, such as radiation injury or collateral thermal damage, due to the inflammation from the necrosis. Therefore, a new physical non-inflammatory therapy based on a non-thermal effect is highly desirable. Here, we report highly efficient apoptosis, reaching nearly 99% in breast cancer cells, one of the human epithelial cells, induced by the non-thermal effect of high-field (average field strength of ~ 5.87 MV/cm) broadband terahertz (THz) waves via double-strand breaks of DNA damage after 4 h of irradiation. This is accompanied by 11 highly differentially expressed genes related to apoptosis and significant morphological changes in the cells. These results suggest that the non-thermal effect of high-field broadband THz waves could be used to develop a potential novel, noninvasive, and non-inflammatory therapy for human superficial tumors.

Indexed as

ApoptosisDNA Breaks, Double-StrandedEpithelial CellsTerahertz RadiationCell Line, TumorDNA DamageHumansApoptosisDNA damageDouble-strand breakHigh-field terahertz wavesHuman epithelial cells.Non-thermal effect

Identifiers

PMID41580463
PMCPMC12905293

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.