Evidence map›Paper›PMID 41580472›Full record

ArticleScientific reports2026

An integrative approach to identify novel miRNA-mRNA interaction networks in LMNA-cardiomyopathy.

José Córdoba-Caballero, Fernando Bonet, Oscar Campuzano, Georgia Sarquella-Brugada, Ignacio Perez de Castro, Borja Vilaplana-Martí, Pedro Seoane-Zonjic, Alipio Mangas, Juan A G Ranea, Rocio Toro

Erratum issuedAbstract read
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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

José Córdoba-Caballero *Biomedical Research and Innovation Institute of Cadiz (INiBICA), Research Unit, Puerta del Mar University Hospital, Cádiz, Spain.
Fernando Bonet *Medicine Department, Medical School of Cádiz, Cádiz University, 11003, Cádiz, Spain.
Oscar CampuzanoMedical Science Department, School of Medicine, University of Girona, Girona, Spain. oscar@brugada.org.ORCID http://orcid.org/0000-0001-5298-5276
Georgia Sarquella-BrugadaMedical Science Department, School of Medicine, University of Girona, Girona, Spain.
Ignacio Perez de CastroInstituto de Investigación de Enfermedades Raras , Instituto de Salud Carlos III, Madrid, Spain.
Borja Vilaplana-MartíServicio Cirugía Experimental, Instituto Aragonés Ciencias de la Salud (IACS), Zaragoza, Spain.
Pedro Seoane-ZonjicDepartment of Molecular Biology and Biochemistry, University of Málaga, Malaga, Spain.
Alipio MangasBiomedical Research and Innovation Institute of Cadiz (INiBICA), Research Unit, Puerta del Mar University Hospital, Cádiz, Spain.
Juan A G RaneaInstituto de Investigación de Enfermedades Raras , Instituto de Salud Carlos III, Madrid, Spain.
Rocio ToroBiomedical Research and Innovation Institute of Cadiz (INiBICA), Research Unit, Puerta del Mar University Hospital, Cádiz, Spain. rocio.toro@uca.es.ORCID http://orcid.org/0000-0003-3136-1776

Funding

European Regional Development Fund ITI0017-2019Fundacion Progreso y Salud PEER 2020-019Institute of Health Carlos III (project IMPaCT-Data) IMP/00019Spanish Ministry of Economy and Competitiveness PID2022-140047OB-C21
6 · The paper itself

Abstract

Dilated cardiomyopathy caused by variants in the LMNA gene leads to malignant arrhythmogenic events, faster phenotype progression and high risk of sudden cardiac death. The pathophysiological mechanisms triggering disease progression remains poorly understood. We investigated the mRNA and miRNA transcriptome in the myocardial tissue of 50-week-old LMNA

Indexed as

Cardiomyopathy, DilatedGene Regulatory NetworksLamin Type AMicroRNAsRNA, MessengerAnimalsGene Expression ProfilingGene Expression RegulationMiceMyocardiumLamin Type ALmna protein, mouseMicroRNAsRNA, MessengerBiological pathwaysLMNA-related dilated cardiomyopathyMicroRNAmiRNA-gene interactionmRNARNA-sequencing

Identifiers

PMID41580472
PMCPMC12901163

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.