ArticleClinical proteomics2026
Comprehensive analysis of proteomics and lactylation proteomics in ovarian granulosa cells of patients with polycystic ovary syndrome.
Article in Clinical proteomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Lactate metabolism and lactylation in female reproductive diseases: From metabolic rewiring to biomarkers and translational therapeutics.Clinical and translational medicine · 2026Review
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Authors and funding
12 authors.
Funding
Abstract
backgroundPolycystic ovary syndrome (PCOS) is a complex and heterogeneous metabolic disorder that affects 6-20% of women of reproductive age. However, research on the lactylation-modified proteome in PCOS remains limited.
methodsThis study included 30 patients with PCOS and 30 control subjects, all of whom underwent intracytoplasmic sperm injection or in vitro fertilization-embryo transfer treatments at the fertility center between October 2022 and May 2023. A 4-dimensional label-free proteomic quantitation method was applied to analyze enzymatically digested peptide fragments of granulosa cell proteins. Liquid chromatography-mass spectrometry was used for protein identification and quantification.
resultsBioinformatics analysis of differentially expressed proteins (DEPs) and differentially lactylated proteins identified 1057 DEPs between the two groups. Among these, 478 proteins were upregulated, and 579 were downregulated in the PCOS group. Regarding lactylation modifications, 668 proteins exhibited increased lactylation levels, while 1059 proteins indicated decreased lactylation levels in the PCOS group. Additionally, site-level analysis revealed 1041 upregulated and 2143 downregulated lactylation sites in the PCOS group.
conclusionsThis study provides a comprehensive quantitative overview of proteomic and lactylation-modified proteomic expression profiles in granulosa cells from patients with PCOS, offering novel insights into PCOS research. Further research is needed to clarify the specific roles of protein lactylation in PCOS pathogenesis.
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