SynthesisBMC geriatrics2026
Association between osteosarcopenia and frailty in older adults: a systematic review and meta-analysis.
Synthesis in BMC geriatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Enhanced Metabolic Risks in Patients with Obesity and Nutritional Deficiencies in the U.S.: A TriNetX Study.Nutrients · 2026Article
- Association between stride length variability and osteosarcopenia in community-dwelling older women: a cross-sectional study.BMC geriatrics · 2026Article
- The crossroads between osteosarcopenia and intrinsic capacity-a narrative review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Review
- Why Osteosarcopenia Matters: Clinical and Investigative Implications.European journal of clinical investigation · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteosarcopenia, the coexistence of sarcopenia and osteoporosis/osteopenia, is an emerging geriatric syndrome, but its relationship with frailty remains unclear.
methodsFollowing PRISMA guidelines, we searched six databases (PubMed, Web of Science, Cochrane Library, Scopus, CINAHL, Embase) from inception to September 6, 2025. Observational studies on the association between osteosarcopenia and frailty were included. Meta-analysis was conducted using STATA 17.0, and subgroup analysis, sensitivity analysis, and assessment of publication bias were also performed.
resultsA total of 11 studies involving 9939 participants were included. Meta-analysis showed that osteosarcopenia was significantly associated with higher odds of frailty (OR = 5.27, 95% CI: 3.75-7.39). Among individuals with osteoporosis/osteopenia, the presence of sarcopenia was associated with 3.78-fold higher odds of frailty (95% CI: 2.95-4.85). Among those with sarcopenia, the presence of osteoporosis/osteopenia was associated with 1.57-fold higher odds of frailty (95% CI: 1.23-2.01). Subgroup analysis revealed that the association between osteosarcopenia and frailty remained consistent and significant across studies from different regions, populations, study designs, and diagnostic criteria.
conclusionsOsteosarcopenia is significantly associated with higher odds of frailty in older adults. However, most included studies were cross-sectional, limiting causal inference. Prospective studies with standardized diagnostic criteria are needed to establish causality and inform prevention strategies.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.