Evidence map›Paper›PMID 41580625›Full record

Observational studyBMC anesthesiology2026

Heightened propofol sensitivity and distinct electroencephalographic signatures in patients with valvular heart disease.

Yu Mao, Ying Shi, Liying Zhu, Qingwei Wei, Ziqing He, Xiangjie Song, Xiaodong Dai, Jingjing He, Lei Zhang, Erwei Gu and 2 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC anesthesiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yu Mao *Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China. Yumao@mail.ustc.edu.cn.
Ying Shi *Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
Liying Zhu *Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
Qingwei WeiDepartment of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
Ziqing HeDepartment of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
Xiangjie SongCore Facility Centre for Life Science, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China.
Xiaodong DaiDepartment of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
Jingjing HeDepartment of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
Lei ZhangDepartment of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
Erwei GuDepartment of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
Guanghong XuDepartment of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
Yan JinStroke Center and Department of Neurology, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230022, PR China.

Funding

National Natural Science Foundation of China 82401441National Natural Science Foundation of China 82471285Natural Science Foundation of Anhui Province 2308085Y24Outstanding Scientific Research and Innovation Team Program for Universities in Anhui Province 2024AH010015
6 · The paper itself

Abstract

objectiveThe significant association between anesthetic sensitivity and postoperative outcomes in patients with valvular heart disease (VD) underscores the critical need for more reliable depth-of-anesthesia monitoring. This study sought to investigate propofol sensitivity and establish specific electroencephalography (EEG) biomarkers to guide safer anesthesia delivery in this high-risk population.

methodsIn this prospective observational trial, 40 patients (20 VD vs. 20 non-cardiac controls) received Schnider model-guided propofol target-controlled infusion. Primary outcome was effect-site propofol concentration at loss of consciousness (Ce

resultsVD patients exhibited 34% lower Ce

conclusionsVD is associated with heightened propofol sensitivity and distinct EEG signatures, including patterns suggestive of thalamocortical dysrhythmia and cortical suppression. These findings suggest that disease-specific EEG monitoring may inform the development of precision anesthesia protocols for cardiac populations.

Indexed as

Anesthetics, IntravenousElectroencephalographyHeart Valve DiseasesPropofolAgedFemaleHumansMaleMiddle AgedProspective StudiesAnesthetics, IntravenousPropofolBurst suppressionDepth of anesthesiaElectroencephalography (EEG)PropofolValvular heart disease

Identifiers

PMID41580625
PMCPMC13011659

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.