Evidence map›Paper›PMID 41580794›Full record

ArticleTrials2026

Noninvasive BCI-based cognitive rehabilitation in poststroke cognitive impairment: study protocol for a randomized controlled trial.

Xinyue Niu, Min Yuan, Jie Zhang, Jie Yang, Qian Yu, Dong Wang

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xinyue NiuSchool of Preclinical Medicine and School of Nursing, Chengdu University, Chengdu, China.
Min YuanDepartment of Rehabilitation, Affiliated Hospital and Clinical Medical College of Chengdu University, Chengdu, China.
Jie ZhangNursing Department, Affiliate hospital of Chengdu University, Chengdu, China.
Jie YangDepartment of Physical Medicine and Rehabilitation, Montefiore Medical Center Albert Einstein College of Medicine, New York, USA.
Qian YuDepartment of Rehabilitation Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Dong WangDepartment of Rehabilitation Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China. wangdong@cdu.edu.cn.ORCID http://orcid.org/0000-0001-5092-8729

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPoststroke cognitive impairment (PSCI) significantly reduces quality of life and survival rates. Current interventions face challenges in efficacy and accessibility. Noninvasive brain-computer interface (BCI) technology may enhance neural plasticity and cognitive recovery through real-time neurofeedback, offering a safe and accessible approach for poststroke cognitive rehabilitation. This trial aims to evaluate the efficacy of BCI-based cognitive training and explore its neural mechanisms.

methodsA prospective, randomized, double-blind, controlled, single-center trial will enroll 66 PSCI patients. Participants will be randomized into the intervention group or control group. Interventions will be administered 5 days/week for 4 weeks. Primary outcome is as follows: The 4-week post-intervention MoCA scores; secondary outcomes are as follows: 3-month follow-up MoCA scores, attention, memory, executive function, neurophysiological markers, and daily living function. Assessments will be conducted at baseline (T DISCUSSION: Results will provide evidence for BCI's clinical utility and neuroplasticity mechanisms, guiding personalized neurorehabilitation strategies. TRIAL STATUS: The protocol version used for this study is Version 3.0, dated May 8, 2025. Recruitment is scheduled to begin on June 10, 2025, and is expected to be completed by May 8, 2026.

trial registrationChinese Clinical Trial Registry ChiCTR2500107318. Registered on 8 August 2025.

Indexed as

Brain-Computer InterfacesCognitionCognitive DysfunctionNeurofeedbackStrokeStroke RehabilitationCognitive EnhancementCognitive TrainingDouble-Blind MethodExecutive FunctionFemaleHumansMaleMemoryNeuronal PlasticityProspective StudiesBrain-computer interfaceCognitive impairmentNeuroplasticityRandomized controlled trialStroke

Identifiers

PMID41580794
PMCPMC12911009

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.