Evidence map›Paper›PMID 41580815›Full record

ReviewJournal of translational medicine2026

Healing dynamics and surgery in breast cancer: rethinking a timeless challenge in light of advancing therapies and technologies.

Stefano Vinci, Roberta Biciuffi, Elena Barbieri, Giosuè Annibalini, Mauro De Santi, Daniela Lucini, Daniela Bosisio, Carolina Gaudenzi, Nicoletta Gagliano, Romano Demicheli and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Stefano Vinci *Department of Biomedical Science for Health, University of Milan, Milan, Italy.
Roberta Biciuffi *Department of Biomedical and Clinical Sciences, Medical Statistics Unit, "Luigi Sacco" University Hospital, University of Milan, Milan, 20157, Italy.
Elena BarbieriDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Giosuè AnnibaliniDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Mauro De SantiDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Daniela LuciniBIOMETRA Department, University of Milan, Milan, Italy.
Daniela BosisioDepartment of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Carolina GaudenziDepartment of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Nicoletta GaglianoDepartment of Biomedical Science for Health, University of Milan, Milan, Italy.
Romano DemicheliDepartment of Biomedical and Clinical Sciences, Medical Statistics Unit, "Luigi Sacco" University Hospital, University of Milan, Milan, 20157, Italy.
Elia BiganzoliDepartment of Biomedical and Clinical Sciences, Medical Statistics Unit, "Luigi Sacco" University Hospital, University of Milan, Milan, 20157, Italy.
Elda TagliabueDepartment of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Francesca BianchiDepartment of Biomedical Science for Health, University of Milan, Milan, Italy. francesca.bianchi1@unimi.it.ORCID http://orcid.org/0000-0001-5197-5279

Funding

European Union - Next Generation EU G53D12001480006European Union - Next Generation EU G53D23000420006European Union - Next Generation EU J13C22000430001
6 · The paper itself

Abstract

backgroundDuring the last century, surgery became the primary approach for treating breast cancer. However, the introduction of new surgical techniques, increasingly less invasive and more conservative, did not always provide consistent benefits in inhibiting tumor progression. MAIN BODY: Inflammatory mechanisms involved in wound repair of surgical damage play a significant role in the progression of cancer. In this review we focused on the healing-induced inflammation processes that can favor residual tumor cells and on the latest current methods, which improve the rate of total tumor excision during the first operation or contribute to diminish host systemic inflammation boosting immune system activation in breast cancer patients.

conclusionsSurgery is still a crucial area of breast cancer research that attempts to understand how it might affect breast cancer progression and, ultimately, survival outcomes.

Indexed as

Breast NeoplasmsWound HealingAnimalsFemaleHumansInflammationTumor MicroenvironmentBreast cancerHistologyRadiomicsSurgerySurgical techniquesTumor microenvironmentWound healing

Identifiers

PMID41580815
PMCPMC12915002

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.