Evidence map›Paper›PMID 41580974›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

A Non-Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation.

Xingxian Zhang, Xinlei Mo, Xinyu Zhou, Xiaoliang Liu, Guizhi Li, Songhui Hu, Yangyang Lu, Chenze Zhu, Jinxi Feng, Zhitong Chen and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xingxian ZhangInstitute of Pharmacology & Toxicology, Zhejiang Key Laboratory of Neuropsychopharmacology, State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Xinlei MoInstitute of Pharmacology & Toxicology, Zhejiang Key Laboratory of Neuropsychopharmacology, State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Xinyu ZhouInstitute of Pharmacology & Toxicology, Zhejiang Key Laboratory of Neuropsychopharmacology, State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Xiaoliang LiuInstitute of Pharmacology & Toxicology, Zhejiang Key Laboratory of Neuropsychopharmacology, State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Guizhi LiSchool of Pharmacy, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Songhui HuJinhua Institute of Zhejiang University, Jinhua, Zhejiang, China.
Yangyang LuInstitute of Pharmacology & Toxicology, Zhejiang Key Laboratory of Neuropsychopharmacology, State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Chenze ZhuInstitute of Pharmacology & Toxicology, Zhejiang Key Laboratory of Neuropsychopharmacology, State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Jinxi FengInstitute of Pharmacology & Toxicology, Zhejiang Key Laboratory of Neuropsychopharmacology, State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Zhitong ChenInstitute of Pharmacology & Toxicology, Zhejiang Key Laboratory of Neuropsychopharmacology, State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Weiwei HuDepartment of Pharmacology and Department of Pharmacy of the Second Affiliated Hospital, School of Basic Medical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Yihui CuiDepartment of Neurobiology, Department of Neurology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Zhong ChenInstitute of Pharmacology & Toxicology, Zhejiang Key Laboratory of Neuropsychopharmacology, State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Xiangnan ZhangInstitute of Pharmacology & Toxicology, Zhejiang Key Laboratory of Neuropsychopharmacology, State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.ORCID https://orcid.org/0000-0002-7603-7403

Funding

Jinhua Science and Technology Plan Projects 2023-3-170Key Research and Development Program of Zhejiang Province 2025C02109National Natural Science Foundation of China 82173792National Natural Science Foundation of China 82373923
6 · The paper itself

Abstract

Mitochondrial quality is crucial for maintaining brain homeostasis. BNIP3L/NIX, a mitophagy receptor, has been linked to neurological disorders, yet its specific function in the brain remains unclear. We found BNIP3L highly expressed in basolateral amygdala (BLA) neurons. Selective deletion of bnip3l in BLA glutamatergic neurons (BLA

Indexed as

AmygdalaFearMembrane ProteinsMemoryMitochondrial ProteinsNeuronsAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutMitochondriaMitochondrial DynamicsMitophagyMembrane ProteinsMitochondrial ProteinsNix protein, mouseAMPK‐Drp1basolateral amygdalaBNIP3L/NIXcontextual fear memorymitochondrial fission

Identifiers

PMID41580974
PMCPMC13042501

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.