Evidence map›Paper›PMID 41580979›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Inhibition of SLC11A1-Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke.

Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia and 2 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lingling QiuDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.ORCID https://orcid.org/0000-0002-3215-2338
Yajie ZhangDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Yushi TangDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Hongli HuJiangsu Key Laboratory of Drug Discovery and Translational Research For Brain Diseases, Institute of Neuroscience, Soochow University, Suzhou, China.
Ying ZhangJiangsu Key Laboratory of Drug Discovery and Translational Research For Brain Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, China.
Junwen XueDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Hao WangJiangsu Key Laboratory of Drug Discovery and Translational Research For Brain Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, China.
Yecheng WangJiangsu Key Laboratory of Drug Discovery and Translational Research For Brain Diseases, Institute of Neuroscience, Soochow University, Suzhou, China.
Chunfeng LiuDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Jia JiaJiangsu Key Laboratory of Drug Discovery and Translational Research For Brain Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, China.
Jian ChengJiangsu Key Laboratory of Drug Discovery and Translational Research For Brain Diseases, Institute of Neuroscience, Soochow University, Suzhou, China.
Yongjun CaoDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.ORCID https://orcid.org/0000-0002-8135-8914

Funding

National Natural Science Foundation of China 32271033National Natural Science Foundation of China 81971119National Natural Science Foundation of China 82071469National Natural Science Foundation of China 82171296National Natural Science Foundation of China 82271315Research Center for Neurological DiseasesSecond Affiliated Hospital of Soochow University ND2024A03Taizhou Municipal Science and Technology Bureau 25ywb95
6 · The paper itself

Abstract

White matter stroke (WMS) results in demyelinating changes and neurological deficits. However, the underlying molecular mechanisms of demyelination after stroke and the specific role of microglia in white matter rehabilitation remain incompletely elucidated. This study identifies a time-dependent accumulation of iron in microglial lysosomes mediated by solute carrier family 11 member 1 (SLC11A1), which persists from 12 h to 14 days following WMS. This iron accumulation results in damaged lysosomal myelin debris uptake and degradation in microglia. Notably, iron chelation with deferoxamine (DFO), microglia-specific knockdown of SLC11A1, and administration of LM22B-10, a SLC11A1 antagonist identified in this study, effectively reduce lysosomal iron accumulation in microglia, enhance microglial uptake and clearance of myelin debris, and ultimately promote functional recovery after WMS. Furthermore, SLC11A1 functions as a H

Indexed as

Cation Transport ProteinsIronLysosomesMicrogliaStrokeWhite MatterAnimalsDisease Models, AnimalMiceNatural Resistance-associated Macrophage Protein 1Cation Transport ProteinsIronNatural Resistance-associated Macrophage Protein 1iron accumulationlysosomesmicrogliasolute carrier family 11 member 1(SLC11A1), white matter stroke(WMS)

Identifiers

PMID41580979
PMCPMC13045239

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.