Evidence map›Paper›PMID 41582001›Full record

ArticleRenal failure2026

Long-term real-world outcomes of rituximab in primary membranous nephropathy: a 154-patient cohort study from China.

Yan Qi, Xin Cao, Xi-Qian Gao, Xi Cheng, Ying-Xin Fang, Xin-Xin Zhang, Zhen-Feng Zheng, Li Wei, Wen-Ya Shang, Jun-Ya Jia and 3 more

Abstract read
In one paragraph

Article in Renal failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yan QiDepartment of Nephrology, Kidney Disease Medical Center, Tianjin Medical University General Hospital, National Key Clinical Specialty, Tianjin Key Medical Discipline, Tianjin, China.ORCID 0009-0006-0668-6535
Xin CaoDepartment of Nephrology, Tianjin Medical University General Hospital Airport Hospital, Tianjin, China.ORCID 0009-0008-7634-835X
Xi-Qian GaoDepartment of Nephrology, Tianjin Medical University General Hospital Airport Hospital, Tianjin, China.ORCID 0000-0003-2056-6880
Xi ChengDepartment of Nephrology, Kidney Disease Medical Center, Tianjin Medical University General Hospital, National Key Clinical Specialty, Tianjin Key Medical Discipline, Tianjin, China.ORCID 0009-0006-2075-7985
Ying-Xin FangDepartment of Nephrology, Kidney Disease Medical Center, Tianjin Medical University General Hospital, National Key Clinical Specialty, Tianjin Key Medical Discipline, Tianjin, China.ORCID 0000-0001-5539-6880
Xin-Xin ZhangDepartment of Nephrology, Kidney Disease Medical Center, Tianjin Medical University General Hospital, National Key Clinical Specialty, Tianjin Key Medical Discipline, Tianjin, China.ORCID 0000-0002-2344-2624
Zhen-Feng ZhengDepartment of Nephrology, Kidney Disease Medical Center, Tianjin Medical University General Hospital, National Key Clinical Specialty, Tianjin Key Medical Discipline, Tianjin, China.ORCID 0000-0001-5065-9039
Li WeiDepartment of Nephrology, Kidney Disease Medical Center, Tianjin Medical University General Hospital, National Key Clinical Specialty, Tianjin Key Medical Discipline, Tianjin, China.ORCID 0009-0000-5777-593X
Wen-Ya ShangDepartment of Nephrology, Kidney Disease Medical Center, Tianjin Medical University General Hospital, National Key Clinical Specialty, Tianjin Key Medical Discipline, Tianjin, China.ORCID 0009-0003-7014-6590
Jun-Ya JiaDepartment of Nephrology, Kidney Disease Medical Center, Tianjin Medical University General Hospital, National Key Clinical Specialty, Tianjin Key Medical Discipline, Tianjin, China.ORCID 0009-0006-9591-3049
Tie-Kun YanDepartment of Nephrology, Kidney Disease Medical Center, Tianjin Medical University General Hospital, National Key Clinical Specialty, Tianjin Key Medical Discipline, Tianjin, China.ORCID 0000-0001-8211-0294
Peng-Cheng XuDepartment of Nephrology, Kidney Disease Medical Center, Tianjin Medical University General Hospital, National Key Clinical Specialty, Tianjin Key Medical Discipline, Tianjin, China.ORCID 0000-0001-8596-9555
Qiu-Hua GuDepartment of Nephrology, Kidney Disease Medical Center, Tianjin Medical University General Hospital, National Key Clinical Specialty, Tianjin Key Medical Discipline, Tianjin, China.ORCID 0000-0002-3389-5950

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To investigate the long-term efficacy and safety of rituximab (RTX) in treating patients with primary membranous nephropathy (pMN), a total of 154 patients with pMN receiving RTX treatment were retrospectively enrolled in this study. The study included 92 patients who received RTX as an initial therapy, and 62 patients who received it as an alternative therapy. Over a median follow-up of 30.0 (24.0, 47.0) months after RTX treatment, 102/121 (84.3%) patients achieved immunological remission. And 128/154 (83.1%) patients achieved clinical remission (including 37.7% of CR and 45.5% of PR), accompanied by significant reduction in proteinuria and increase in serum albumin levels. Clinical response rates were comparable between the initial and alternative therapy groups (87.0 vs. 77.4%,

Indexed as

Glomerulonephritis, MembranousImmunologic FactorsKidney Failure, ChronicRituximabAdultChinaFemaleFollow-Up StudiesGlomerular Filtration RateHumansImmunosuppressive AgentsMaleMiddle AgedProteinuriaRemission InductionRetrospective StudiesImmunologic FactorsImmunosuppressive AgentsRituximabanti-PLA2R antibodypredictorsPrimary membranous nephropathyreal-world evidencerenal survivalrituximab

Identifiers

PMID41582001
PMCPMC12833891

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.