Evidence map›Paper›PMID 41582117›Full record

ArticleAIDS research and therapy2026

Pregnancies, live births, and heart structure and function in women with HIV.

Yue Pan, Vikasni Mohan, Valeria Londono, Yawen Lu, Nicholas Fonseca, Weiqun Tong, Michelle Floris-Moore, Aruna Chandran, Yasmeen Golzar, Phyllis Tien and 13 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS research and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Yue PanDepartment of Public Health, University of Miami Miller School of Medicine, Miami, FL, USA.
Vikasni MohanDepartment of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.
Valeria LondonoGeorgetown University School of Medicine, Washington, DC, USA.
Yawen LuDepartment of Public Health, University of Miami Miller School of Medicine, Miami, FL, USA.
Nicholas FonsecaDepartment of Medicine, Division of Infectious Disease, University of Miami Miller School of Medicine, Miami, FL, USA.
Weiqun TongDepartment of Epidemiology, Johns Hopkins University, Baltimore, MD, USA.
Michelle Floris-MooreDepartment of Medicine, Division of Infectious Disease, University of North Carolina, Chapel Hill, NC, USA.
Aruna ChandranDepartment of Epidemiology, Johns Hopkins University, Baltimore, MD, USA.
Yasmeen GolzarCook County Hospital, Division of Cardiology, Chicago, IL, USA.
Phyllis TienDepartment of Medicine, Division of Infectious Disease, University of San Francisco, San Francisco, CA, USA.
Jorge R KizerCardiology Section, San Francisco Veterans Affairs Health Care System, Department of Medicine, Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Daniel MerensteinGeorgetown University Department of Family Medicine, Washington, DC, USA.
Howard MinkoffSUNY Downstate School of Public Health and Maimonides Medical Center, New York, NY, USA.
Anandi N ShethDepartment of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA.
Anna BortnickDepartment of Medicine, Division of Cardiology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY, USA.
Jodie A DionneDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Margaret A FischlDepartment of Medicine, Division of Infectious Disease, University of Miami Miller School of Medicine, Miami, FL, USA.
Maureen LoweryDepartment of Medicine, Cardiovascular Division, University of Miami Miller School of Medicine, Miami, FL, USA.
Angela M BengtsonDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Caitlin A MoranDepartment of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA.
Deborah JonesBehavioral Medicine Research Center, University of Miami, Miami, FL, USA.
Maria L AlcaideDepartment of Medicine, Division of Infectious Disease, University of Miami Miller School of Medicine, Miami, FL, USA.
Claudia A MartinezDepartment of Medicine, Cardiovascular Division, University of Miami Miller School of Medicine, Miami, FL, USA. cmartinez5@miami.edu.ORCID 0000-0002-2489-6193

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul A. Goepfert · 1988 to 2026
$84.1M
Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
SF Bay Area MACS/WIHS Combined Cohort StudyU01HL146242 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Bradley E Aouizerat, Jennifer Cohen Price · 2019 to 2026
$36.3M
Sex differences in the role of multi-omicsin HIV-associated carotid artery atherosclerosisU01HL146193 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Stephen J Gange, Elizabeth Topper · 2019 to 2026
$35.8M
University of Miami Developmental Center for AIDS Research (D-CFAR)P30AI073961 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Savita Pahwa · 2007 to 2026
$33.8M
Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center - Admin Supplement: Vision and dual sensory loss in HIV-infected older adultsU01HL146201 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TODD T BROWN, Joseph B. Margolick · 2019 to 2026
$33.7M
Sex differences in the role of multi-omics in HIV-associated carotid artery atherosclerosisU01HL146204 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI David B. Hanna, Anjali Sharma · 2019 to 2026
$33.2M
NCATS NIH HHS KL2 TR001432NCATS NIH HHS TL1 TR001431NCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1 TR001409NCATS NIH HHS UL1 TR001881NCATS NIH HHS UL1 TR003098NHLBI NIH HHS K23 HL146982NHLBI NIH HHS U01 HL146192NHLBI NIH HHS U01 HL146193NHLBI NIH HHS U01 HL146194NHLBI NIH HHS U01 HL146201NHLBI NIH HHS U01 HL146202NHLBI NIH HHS U01 HL146203NHLBI NIH HHS U01 HL146204NHLBI NIH HHS U01 HL146205NHLBI NIH HHS U01 HL146208NHLBI NIH HHS U01 HL146240NHLBI NIH HHS U01 HL146241NHLBI NIH HHS U01 HL146242NHLBI NIH HHS U01 HL146245NHLBI NIH HHS U01 HL146333NIAID NIH HHS P30 AI027767NIAID NIH HHS P30 AI050409NIAID NIH HHS P30 AI050410NIAID NIH HHS P30 AI073961NIAID NIH HHS P30 AI124414NIMH NIH HHS P30 MH116867
6 · The paper itself

Abstract

objectiveWomen with HIV (WWH) have up to five times higher risk for cardiovascular disease compared to age-matched women without HIV, and this risk is pronounced in reproductive-aged women. Pregnancy promotes systemic inflammation, leading to remodeling of the heart's structure and changes in function during and after pregnancy; therefore, we sought to examine the association of pregnancy history and number of live births with changes in cardiac structure and function in women with and without HIV (WWoH).

methodsCross-sectional data from the Multicenter AIDS Cohort Study/Women's Interagency HIV Study Combined Cohort Study (MWCCS) were analyzed using univariate and multivariable logistic and linear regression models. Data from participants with echocardiograms conducted during or after their last pregnancy were included. The association between echocardiographic parameters and ever having had a live birth and number of live births was examined by HIV status.

resultsOf 1,646 women (1,156 WWH and 490 WWoH), 83% (n = 1,369) had a history of live births. Among WWH, ever having a live birth was associated with decreased left ventricular ejection fraction (β=-1.33, p = 0.014) and number of live births was associated with increased odds of diastolic dysfunction (OR = 1.14, p = 0.009). In WWoH, live births were significantly associated with increased left ventricular end-diastolic volume index (β = 0.64, p = 0.029).

conclusionIn this study, live birth history was associated with small but significant changes in cardiac structure and function, with WWH showing greaterlikelihood of adverse echocardiographic changes. This highlights differential cardiac remodeling patterns by HIV status. Longitudinal studies are needed to assess the progression and clinical implications of these findings.

Indexed as

HeartHIV InfectionsLive BirthPregnancy Complications, InfectiousAdultCross-Sectional StudiesEchocardiographyFemaleHumansPregnancyStroke VolumeCardiovascularEchocardiogramHeart structure and functionHIVLive birthsPregnancy

Identifiers

PMID41582117
PMCPMC12914884

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.