ArticleBMC pediatrics2026
Molecular profile of pediatric pseudotumor cerebri: the role of apelin isoforms and oxidative stress.
Article in BMC pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundApelin is an endogenous ligand of the apelin receptor (APJ), expressed in multiple tissues, including the brain and heart. Isoforms such as apelin-13 and apelin-36 play protective roles in pathological processes, including oxidative stress, inflammation, apoptosis, and autophagy. This study aimed to examine the relationship between apelin and oxidative stress in pediatric pseudotumor cerebri syndrome (PTCS).
methodsIn this cross-sectional, case-control study, serum samples were obtained from 33 children with PTCS and 44 age- and sex-matched healthy controls between September 2023 and August 2024. Demographic and clinical data, including age, sex, MRI findings, papilledema grade, and treatment history, were recorded. Serum apelin-13, apelin-36, total oxidant status (TOS), and total antioxidant status (TAS) were measured using ELISA.
resultsChildren with PTCS demonstrated higher papilledema grades and more frequent MRI abnormalities compared with controls. Elevated apelin-13 levels were significantly associated with abnormal MRI findings (p = 0.022). TOS levels were lower in patients with grade 3 papilledema (p = 0.006). Apelin-36 levels were higher in PTCS cases and were significantly associated with treatment status (p = 0.022). A positive correlation was observed between apelin-13 and apelin-36 (r = 0.340). Regression analysis indicated that a 1-standard-deviation increase in apelin-36 was associated with a 1.035-fold increase in the risk of PTCS (p = 0.012).
conclusionApelin-36 appears to be a promising biomarker for PTCS, reflecting both the presence and severity of the disease. Apelin-13 was associated with radiological findings of idiopathic intracranial hypertension. Further studies are warranted to clarify the role of apelin isoforms and oxidative stress markers in PTCS pathophysiology.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.