Evidence map›Paper›PMID 41583012›Full record

ArticleThe journal of allergy and clinical immunology. Global2026

Evidence for dysbiosis in the gut microbiome of patients with systemic mastocytosis.

Lauren E Krausfeldt, Vivian Cao, Richard Rodrigues, Wendy A Henderson, Robin Eisch, Linda M Scott, Dean D Metcalfe, Hirsh D Komarow

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of allergy and clinical immunology. Global, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00044122 (Regulation of the Proliferation and Survival of Normal and Neoplastic Human Mast Cells), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00044122 recruitingnot on this map

Regulation of the Proliferation and Survival of Normal and Neoplastic Human Mast Cells

TypeobservationalSponsorNational Institute of Allergy and Infectious Diseases (NIAID)Ran2002Enrolled600ConditionsMastocytosis, Monoclonal, Bone Marrow, Tryptase
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lauren E KrausfeldtBioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Vivian CaoMast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Richard RodriguesMicrobiome and Genetics Core, Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, Md.
Wendy A HendersonDigestive Disorders Unit, National Institute of Nursing, National Institutes of Health, Bethesda, Md.
Robin EischMast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Linda M ScottMast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Dean D MetcalfeMast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
Hirsh D KomarowMast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Limited research studies have investigated the role of the gut microbiome in systemic mastocytosis (SM), which is characterized by an aberrant expansion of clonal mast cells in specific tissues including the skin, marrow, liver, and the gastrointestinal tract. Objectives: We sought to investigate the relationship between the intestinal microbiome and clinical manifestations of SM. Methods: The V4 region of the 16S rRNA gene was sequenced from stool samples of 22 patients with SM and 9 healthy controls. Microbial community composition, diversity, and functional genes inferred from 16S rRNA gene sequences were analyzed. ClinicalTrials.gov Identifier NCT00044122. Results: Changes in microbial community composition were associated with SM, KIT D816V, and tryptase (PERMANOVA, Conclusions: Dysbiosis of the gut microbiome is evident in patients with SM and is seemingly associated with mast cell activation. In addition, diet may further alter microbial composition and metabolism in the gut of patients with SM.

Indexed as

BacteroidetesdysbiosisFirmicutesgut microbiomeKIT D816Vmast cell diseasemast cellsshort-chain fatty acidsSystemic mastocytosistryptase

Identifiers

PMID41583012
PMCPMC12826983

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.