ReviewInternational journal of pharmaceutics: X2026
Chitosan-based nanozyme hydrogels: Advanced antioxidant and sustained-release systems for the prevention and treatment of skin photoaging.
Review in International journal of pharmaceutics: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Paeonol-Loaded Cyclodextrin/Composite Hydrogel for Enhanced Transdermal Delivery and Skin Photoaging Repair.Gels (Basel, Switzerland) · 2026Article
- Exosome-Mediated Rewiring of Oxidative Stress-Inflammation-ECM Remodeling Axis Mitigates UVB-Triggered Skin Photoaging.International journal of nanomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Photoaging of the skin is a chronic damage process caused by prolonged exposure to ultraviolet radiation, characterized by increased oxidative stress, activation of inflammatory responses, and collagen degradation. However, photoaging of the skin presents challenges in prevention, limited efficacy of therapeutic agents, and difficulties in repairing the damage. In recent years, chitosan-based hydrogels, which exhibit excellent biocompatibility, biodegradability, film-forming properties, and the ability to deliver sustained-release medication, have progressively emerged as cutting-edge therapeutic agents for treating photoaging of the skin. Nanozymes are nanomaterials possessing enzymatic functions that effectively scavenge reactive oxygen species generated by ultraviolet irradiation, exhibiting excellent antioxidant properties. Loading nanozymes into chitosan-based hydrogels not only combines the biocompatibility of chitosan hydrogels with the antioxidant properties of nanozymes to enhance therapeutic efficacy but also enables stable loading and controlled release of drugs and active ingredients. This further improves treatment efficiency while fully leveraging the moisturizing and restorative properties of the hydrogel matrix. This paper systematically summarizes the construction methods, performance optimization, and mechanism of action of chitosan-based nanozyme hydrogels in preventing and treating skin photoaging. It focuses on analyzing research advances in their capacity to scavenge free radicals, alleviate inflammation, and promote skin barrier repair, while exploring their application prospects and challenges in skin repair and the cosmetics sector.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.