Perioperative Patient Safety and Surgical Complications: A Comprehensive Review of Current Evidence and Improvement Strategies.

Perioperative patient safety has become an increasingly urgent priority as global surgical demand rises and preventable postoperative complications continue to challenge healthcare systems. Despite major advances in anesthesia, surgical technique, and monitoring technologies, many adverse events still originate from modifiable, process-related factors occurring before, during, and immediately after surgery. These events commonly reflect an interaction between patient-specific physiological vulnerability, team performance, system reliability, and organizational culture. This narrative review synthesizes contemporary evidence to examine specific perioperative interventions that have been associated with improved outcomes. Across the literature, early physiological deterioration is consistently identified as a major driver of preventable harm, underscoring the value of structured preoperative risk assessment and targeted optimization, as well as standardized intraoperative safety processes that support reliable team coordination. In the postoperative phase, structured surveillance systems and clearly defined escalation pathways are repeatedly linked to earlier recognition of deterioration and reduced respiratory and hemodynamic instability. The review further highlights the role of teamwork, communication practices, and safety culture as enablers of reliable perioperative care. Institutions that implement structured communication routines, embed safety processes into daily workflows, and support a positive safety climate demonstrate more consistent application of evidence-based interventions and lower rates of preventable complications. Overall, the findings support an integrated, system-level approach in which coordinated perioperative interventions rather than generalized vigilance alone link preoperative planning, intraoperative safety, and postoperative surveillance within a cohesive framework. Strengthening these coordinated processes provides a practical pathway for reducing avoidable harm and improving perioperative outcomes across diverse clinical settings.