Association between spontaneous neurogenic atrophy of the femoral muscle and islet cell tumors in aged F344 rats.

Mitsutoshi Uchida, Yumi Wako, Takeshi Kanno, Natsumi Shimoyama, Yutaka Nakahara, Takuya Doi, Yuki Tomonari, Junko Sato

Abstract read

In one paragraph

Article in Journal of toxicologic pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Mitsutoshi UchidaKashima Pathology Group, Pathology Department, Drug Discovery Regulatory Center, Non-clinical Business Segment, Mediford Corporation, Kamisu-shi, Ibaraki 314-0255, Japan.

Yumi WakoKashima Pathology Group, Pathology Department, Drug Discovery Regulatory Center, Non-clinical Business Segment, Mediford Corporation, Kamisu-shi, Ibaraki 314-0255, Japan.

Takeshi KannoKashima Pathology Group, Pathology Department, Drug Discovery Regulatory Center, Non-clinical Business Segment, Mediford Corporation, Kamisu-shi, Ibaraki 314-0255, Japan.

Natsumi ShimoyamaKashima Pathology Group, Pathology Department, Drug Discovery Regulatory Center, Non-clinical Business Segment, Mediford Corporation, Kamisu-shi, Ibaraki 314-0255, Japan.

Yutaka NakaharaPathology Group, Research UnitII, Drug Discovery Innovation Center, Non-Clinical Business Segment, Mediford Corporation, 1285 Kurizaki-machi, Uto, Kumamoto 869-0425, Japan.

Takuya DoiKashima Pathology Group, Pathology Department, Drug Discovery Regulatory Center, Non-clinical Business Segment, Mediford Corporation, Kamisu-shi, Ibaraki 314-0255, Japan.

Yuki TomonariKashima Pathology Group, Pathology Department, Drug Discovery Regulatory Center, Non-clinical Business Segment, Mediford Corporation, Kamisu-shi, Ibaraki 314-0255, Japan.

Junko SatoKashima Pathology Group, Pathology Department, Drug Discovery Regulatory Center, Non-clinical Business Segment, Mediford Corporation, Kamisu-shi, Ibaraki 314-0255, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In aged F344/DuCrlCrlj rats, we observed that all animals with group atrophy of the biceps femoris muscle also had islet cell tumors, suggesting that spontaneous islet cell tumors may induce peripheral neuropathy and muscle atrophy. Among 220 aged male F344/DuCrlCrlj rats examined, 12.3% (27/220) had islet cell tumors, and of these, 22.2% (6/27) had neurogenic muscular atrophy. Sciatic nerve degeneration was observed in 3.2% (7/220) of cases, and all animals with neurogenic muscular atrophy had sciatic nerve degeneration. Notably, no neurogenic muscular atrophy was observed in rats without islet cell tumors. In contrast, rats with neurogenic muscular atrophy tended to have larger islet cell tumors. Although spinal nerve root degeneration was prevalent (90.8%, 198/218), two of the six rats with neurogenic muscular atrophy did not exhibit this pathology. Immunohistochemically, insulin was positive in all islet cell tumors, although glucagon- and somatostatin-positive reactions showed no association with neurogenic muscular atrophy. Experimentally induced hyperinsulinemia in rats is a known cause of neurogenic muscular atrophy, and similar associations have been reported in humans and spontaneous cases of pet rats with islet cell tumors. A complete coincidence between the occurrence of neurogenic muscular atrophy and islet cell tumors in our investigation suggests that some islet cell tumors in F344/DuCrlCrlj rats may be functionally active, and that hyperinsulinemia may contribute to the pathogenesis of neurogenic muscular atrophy.

Indexed as

F344 rathyperinsulinemiainsulinomaislet cell tumorneurogenic muscular atrophyperipheral neuropathy

Identifiers

PMID41583344

DOI10.1293/tox.2025-0016

PMCPMC12826866

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.