ArticleFrontiers in immunology2025
Antigen binding triggers long-range conformational changes in monoclonal antibodies.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Antigen binding in monoclonal antibodies (mAbs) is traditionally associated with target recognition, but emerging evidence suggests it may also modulate antibody conformation and effector functions. Understanding how antigen engagement impacts the structural organization of therapeutic antibodies and their interaction with immune receptors is essential for optimizing antibody-based therapies. In this study, we investigated, Methods: Accelerated molecular dynamics simulations were performed to investigate the structural and dynamic consequences of antigen binding in two therapeutic mAbs, adalimumab and avelumab. These antibodies were analyzed in different glycosylation states to capture the influence of post translational modifications. Results: Conclusion: These findings suggest that antigen engagement initiates a cascade of coordinated motions that reshape the mAb architecture and regulate its interaction with the immune receptors, offering new insights for the design of functionally optimized therapeutic antibodies.
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