ReviewFrontiers in immunology2025
Engineering neuroimmune regulation: biomaterial and nanotechnology platforms for neuropathology diagnosis and targeted immunomodulation.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Nanoparticle-Based delivery of proteasome inhibitors for glioblastoma Therapy: Strategies to overcome Blood-Brain barrier and therapeutic resistance.Biochemical pharmacology · 2026Review
- The neuroimmune network in Alzheimer's and Parkinson's diseases: from mechanistic insights to biomarker-guided immunotherapies and clinical translation.Inflammopharmacology · 2026Review
- Nanoparticle-delivered immunomodulators targeting blood-brain barrier disruption in fulminant adult-onset ADEM.Annals of medicine and surgery (2012) · 2026Article
- Role of Caveolin-1 in Inflammation: Genetic Predisposition and Potential Implication for Multiple Sclerosis.Genes · 2026Review
- Local Nanomedicine and Nano-Enabled Biomaterials After Glioblastoma Resection.International journal of nanomedicine · 2026Review
- Reprogramming of pathogenic strategies inFrontiers in cellular and infection microbiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The immune system is a potent and interwoven regulator of neuropathology in the central nervous system (CNS). For example, gliomas, neurodegenerative diseases, and autoimmune neuroinflammation all have diverse etiology and pathogenesis. Yet, there are numerous similarities in immunological dysfunction between these neuropathological conditions. Synthesizing this knowledge could inform advanced diagnostics and therapeutic platforms. For instance, detection and precision management of neuroinflammation or blood-brain barrier integrity would be broadly applicable. Understanding the targetable or controllable immune pathways of these disorders and engineering local and systemic interventions are essential for improving disease prognosis. This review integrates and contrasts the biology, detection, and treatment of the aforementioned neuropathologies. First, immunological underpinnings and recent discoveries on the role of innate and adaptive immune cells are discussed. Second, diagnostics that span molecular and nanotechnology-based platforms are detailed for enhanced imaging and screening of neuroinflammation. Last, immunomodulatory therapeutics and the precision of biomaterial platforms for neuroimmune regulation are examined. Within this section on therapeutics, both clinical and experimental approaches are stratified by CNS-localized or systemic mechanism-of-action. Overall, the integration of immunotherapies, biomaterials, advanced drug delivery platforms, and precision medicine will be critical in overcoming current treatment limitations for neuropathology that have few or no therapeutic options.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.