Evidence map›Paper›PMID 41583448›Full record

ArticleFrontiers in immunology2025

Extracellular CIRP augments inflammation in acute kidney injury via NKG2D-positive macrophages.

Fangming Zhang, Hui Jin, Chuyi Tan, Ping Wang, Max Brenner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fangming ZhangCenter for Immunology and Inflammation, The Feinstein Institutes for Medical Research, Manhasset, NY, United States.
Hui JinCenter for Immunology and Inflammation, The Feinstein Institutes for Medical Research, Manhasset, NY, United States.
Chuyi TanCenter for Immunology and Inflammation, The Feinstein Institutes for Medical Research, Manhasset, NY, United States.
Ping Wang *Center for Immunology and Inflammation, The Feinstein Institutes for Medical Research, Manhasset, NY, United States.
Max Brenner *Center for Immunology and Inflammation, The Feinstein Institutes for Medical Research, Manhasset, NY, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The mechanism by which extracellular cold-inducible RNA-binding protein (eCIRP) aggravates renal ischemia/reperfusion (RIR) injury leading to acute kidney injury (AKI) is poorly understood. The natural killer group 2D (NKG2D) receptor and its ligand MULT-1 are key immunoregulatory mechanisms promoting responses to damaged and inflamed cells. Methods: We subjected wild-type and CIRP Results: The expression levels of NKG2D and its ligand MULT-1 were significantly elevated in wild-type mice subjected to RIR compared with sham. In contrast, CIRP Discussion: In conclusion, eCIRP induces NKG2D

Indexed as

Acute Kidney InjuryInflammationMacrophagesNK Cell Lectin-Like Receptor Subfamily KRNA-Binding ProteinsAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, KnockoutReperfusion InjuryCirbp protein, mouseKlrk1 protein, mouseNK Cell Lectin-Like Receptor Subfamily KRNA-Binding ProteinsAKIeCIRPmacrophagesMULT-1NKG2DRIRRTECs

Identifiers

PMID41583448
PMCPMC12823515

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.