ArticleFrontiers in network physiology2025
Spatial and spectral structure of local functional connectivity of the background intracranial EEG in patients with focal epilepsy.
Article in Frontiers in network physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Resting-state EEG markers of cognitive dysfunction in epilepsy: evidence from gamma power, alpha activity, and functional connectivity.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- An update on the network theory of epilepsy.Frontiers in network physiology · 2026Article
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7 authors.
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Abstract
Purpose: To determine the frequency band-related local functional connectivity (BRLFC) of the seizure onset area (SOA) and areas removed from it, and the relationship between BRLFC and outcome of epilepsy surgery. Methods: This study was conducted on 14 unselected adult patients with focal epilepsy undergoing icEEG monitoring for surgery. Intracranial EEG (icEEG) electrode contacts were located from post-implantation CT and MR images and registered to the MRI of a common brain to allow interpretation of results from all patients in the same space. Two 1 h icEEG epochs, recorded during wake and removed in time from seizure occurrence, were studied. One of these epochs was when the subject was on anti-seizure medications (ASMs), while the second was after ASM taper. Coherence was estimated for all pairs of electrode contacts ipsilateral to the SOA in delta, theta, alpha, beta, gamma and a high frequency band. The BRLFC of each electrode contact was estimated as the average band-related coherence between it and all electrode contacts within a spatial window. Key findings: BRLFC in the SOA and peri-SOA, for selected frequency bands, was greater in patients with excellent outcome after surgery in comparison to those with poor outcome. A graded relationship was observed between BRLFC and distance to the SOA of patients with excellent outcome to surgery such that contacts with the greatest connectivity were closer to the SOA and those with the lowest connectivity were several cm from the SOA. This relationship between distance to the SOA and connectivity was present primarily in the alpha, beta, gamma and high frequency bands and the BRLFC was greatest in the peri-SOA, within a distance of 5 cm from the SOA. This relationship was stable between on-ASMs and off-ASMs epochs. Significance: There is stable altered BRLFC in the SOA and peri-SOA expressed in the background icEEG of patients with focal epilepsy. This altered BRLFC may be a network marker of medically intractable focal epilepsy which is related to outcome of epilepsy surgery.
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