ArticleStroke (Hoboken, N.J.)2024
Impact of Sex on Thrombectomy Outcomes in Ischemic Stroke: A Propensity Score-Matched Study, Systematic Review, and Meta-Analysis.
Article in Stroke (Hoboken, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Acute Kidney Injury After Mechanical Thrombectomy for Stroke in Patients With Pre-Existing Renal Impairment.Annals of clinical and translational neurology · 2026Article
- Sex differences in outcomes after endovascular therapy with prior antiplatelet use: A study from the EVA-TRISP registry.European stroke journal · 2025Article
- Sex Differences in Prognostic Markers: Exploring Outcome Variability After Mechanical Thrombectomy in Large Vessel Occlusion Stroke.Journal of clinical medicine · 2025Article
- Sex Differences in Embolic Stroke of Undetermined Source: Echocardiographic Features and Clinical Outcomes.European journal of neurology · 2025Observational
- Sex differences in age-associated neurological diseases-A roadmap for reliable and high-yield research.Science advances · 2025Review
- Sex-based differences in inflammatory predictors of outcomes in patients undergoing mechanical thrombectomy: an inverse probability weighting analysis.Therapeutic advances in neurological disorders · 2025Article
- Sex-Specific Effects of Endovascular Treatment in Large-Vessel Occlusion Stroke.Stroke (Hoboken, N.J.) · 2024Article
- Exploring the Impact of Age and Pre-Stroke Modified Rankin Scale in Elderly Thrombectomy: A 15-Year Single-Center Experience.Cerebrovascular diseases extra · 2024Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Women are underrepresented in stroke thrombectomy trials, and the impact of sex differences in outcomes after stroke thrombectomy is unclear. We performed a multicenter propensity matching study to define sex-related differences in outcome after endovascular thrombectomy and integrated results in a meta-analysis. Methods: We included patients with anterior circulation large vessel occlusion consecutively treated with thrombectomy at 2 Comprehensive Stroke Centres (2016-2023). Selection criteria reflected international guidelines. Through systematic review we selected all studies reporting endovascular thrombectomy outcomes in anterior circulation large vessel occlusion stroke, applying propensity score matching. MEDLINE, EMBASE, and Cochrane CENTRAL were searched up to August 15, 2023 according to predefined protocol (OSF.io/je3da). Data were extracted by 2 independent raters, pooled estimates calculated according to random-effect modeling meta-analysis and reported as odds ratio (OR) and standard 95% CI. Outcomes were good functional outcome, defined as modified Rankin Scale score 0-2 at 90 days after stroke, and symptomatic intracranial hemorrhage, adjudicated according to European Cooperative Acute Stroke Study II criteria. Results: After matching, 698 patients (349 women versus 349 men) had similar cardiovascular risk factors, baseline features, and treatment approach. No significant differences were found for good functional outcome (OR = 0.89, 95% CI = 0.66-1.2) and symptomatic intracranial hemorrhage (OR = 1.00, 95% CI = 0.44-2.26) in the cohort study by sex. Systematic review identified 3 studies (n = 3706), all of high quality. No differences emerged in rates of good functional outcome (OR = 1.00, 95% CI = 0.79-1.21) or symptomatic intracranial hemorrhage (OR = 0.85, 95% CI = 0.60-1.19) depending on sex. Conclusion: Women receiving endovascular thrombectomy for anterior circulation large vessel occlusion related stroke have similar rates of good functional outcome and symptomatic intracranial hemorrhage compared to men.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.