Evidence map›Paper›PMID 41584491›Full record

ArticleStroke (Hoboken, N.J.)2024

Low Cerebral Blood Volume Index, Thrombectomy, and Prior Stroke Are Independently Associated With Hemorrhagic Transformation in Medium-Vessel Occlusion Ischemic Stroke.

Vivek S Yedavalli, Manisha Koneru, Meisam Hoseinyazdi, Elisabeth B Marsh, Rafael H Llinas, Victor Urrutia, Richard Leigh, Luis Fernando Gonzalez, Risheng Xu, Justin Caplan and 10 more

Abstract read
In one paragraph

Article in Stroke (Hoboken, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Association of hypoperfusion intensity ratio and cerebral blood volume Index with good outcome in patients transferred for thrombectomy.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  6. Article
  7. Article
  8. Atrial fibrillation is associated with lower likelihood of first-pass effect in thrombectomy for medium vessel occlusion acute ischemic strokes.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  9. Long-term functional outcomes for elderly patients treated with endovascular thrombectomy.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Vivek S YedavalliDepartment of Radiology and Radiological Sciences Johns Hopkins School of Medicine Baltimore MD.ORCID https://orcid.org/0000-0002-2450-4014
Manisha KoneruCooper Medical School of Rowan University Camden NJ.
Meisam HoseinyazdiDepartment of Radiology and Radiological Sciences Johns Hopkins School of Medicine Baltimore MD.
Elisabeth B MarshDepartment of Neurology Johns Hopkins School of Medicine Baltimore MD.
Rafael H LlinasDepartment of Neurology Johns Hopkins School of Medicine Baltimore MD.
Victor UrrutiaDepartment of Neurology Johns Hopkins School of Medicine Baltimore MD.
Richard LeighDepartment of Neurology Johns Hopkins School of Medicine Baltimore MD.
Luis Fernando GonzalezDepartment of Neurosurgery Johns Hopkins School of Medicine Baltimore MD.
Risheng XuDepartment of Neurosurgery Johns Hopkins School of Medicine Baltimore MD.
Justin CaplanDepartment of Neurosurgery Johns Hopkins School of Medicine Baltimore MD.
Judy HuangDepartment of Neurosurgery Johns Hopkins School of Medicine Baltimore MD.
Hanzhang LuDepartment of Radiology and Radiological Sciences Johns Hopkins School of Medicine Baltimore MD.
Max WintermarkDepartment of Radiology University of Texas MD Anderson Center Houston TX.
Adam A DmytriwDepartment of Neuroradiology Massachusetts General Hospital & Harvard Medical School Boston MA.
Adrien GuenegoDepartment of Radiology Université Libre De Bruxelles Hospital Erasme Bruxelles Belgium.
Gregory W AlbersDepartment of Radiology Stanford University School of Medicine Stanford CA.
Licia LunaDepartment of Radiology and Radiological Sciences Johns Hopkins School of Medicine Baltimore MD.
Jeremy J HeitDepartment of Neurology Stanford University School of Medicine Stanford CA.
Kambiz NaelDepartment of Radiology and Biomedical Imaging University of California San Francisco (UCSF) San Francisco CA.
Argye E HillisDepartment of Neurology Johns Hopkins School of Medicine Baltimore MD.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hemorrhagic transformation (HT) is a major complication in patients with acute ischemic stroke (AIS) treated with endovascular thrombectomy. However, HT in patients with AIS due to medium-vessel occlusions has still not been well researched. In large-vessel occlusions, collateral status is an important determinant of postprocedural HT, and the cerebral blood volume (CBV) index is a reliable surrogate of collateral status. The aim of our study is to identify an optimal CBV index threshold associated with HT in patients with AIS due to medium-vessel occlusion and evaluate additional parameters that are independently associated with HT in this group. Methods: This retrospective analysis of our prospectively collected database from 2 comprehensive stroke centers consisted of patients presenting with AIS due to medium-vessel occlusion from 2019 to 2023. The primary outcome was the presence of HT on follow-up imaging. Optimal CBV index cutoff for HT was derived from a univariate logistic regression analysis. Multivariable logistic regression analysis for HT was derived from the dichotomized CBV index and other covariates. The receiver operator characteristic curve yielded area under the curve. Statistical significance was Results: Of 111 patients (median age, 70 years; 43.2% women) included, 26 (23.4%) patients had HT. The optimal CBV index cutoff was 0.7. From multivariable regression analysis, significant variables included prior stroke (adjusted odds ratio [aOR], 7.18 [95% CI, 1.60-32.16]; Conclusion: A CBV index

Indexed as

acute ischemic strokecerebral blood flowdistal medium‐vessel occlusionlarge‐vessel occlusion

Identifiers

PMID41584491
PMCPMC12778510

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.