ArticlePeerJ2026
Genome-wide association study identifies
Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Genetic factors have been increasingly recognized as important contributors to the development and progression of adolescent idiopathic scoliosis (AIS). However, the genetic basis underlying AIS curve severity remains largely unclear. The objective of this study is to identify novel genetic variants associated with curve severity in AIS through a genome-wide association study (GWAS). Methods: In the discovery stage, 620 female AIS patients were enrolled, including 323 with severe curves (> 40°) and 297 with mild curves (< 30°). Top single nucleotide polymorphisms (SNPs) from each locus were selected for replication in an independent cohort of 634 severe and 546 mild cases. Associations between gene expression and Cobb angle were evaluated using Spearman correlation, while correlations with myofiber-related genes were analyzed using Pearson correlation. Results: Fifteen novel SNPs showed potential association with AIS curve severity in the discovery stage ( Conclusions: This study identified
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.