Evidence map›Paper›PMID 41585176›Full record

ArticleJournal of dental sciences2026

Nuclear factor erythroid 2-related factor 2/heme oxygenase-1 activation by nattokinase reduces pro-inflammatory and matrix-degrading mediators in human gingival fibroblasts.

Ya-Lun Li, Yang-Che Wu, Chien-Fu Tseng, Yung-Li Wang, Sin-Yu Li, Thi Thuy Tien Vo, Yuh-Lien Chen, Yin-Tzer Shih, I-Ta Lee

Abstract read
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In one paragraph

Article in Journal of dental sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ya-Lun LiDepartment of Applied Mathematics, National Chung Hsing University, Taichung, Taiwan.
Yang-Che WuSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Chien-Fu TsengGraduate Institute of Clinical Dentistry, School of Dentistry, College of Medicine, National Taiwan University, Taipei, Taiwan.
Yung-Li WangSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Sin-Yu LiSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Thi Thuy Tien VoFaculty of Dentistry, Nguyen Tat Thanh University, Ho Chi Minh City, Viet Nam.
Yuh-Lien ChenDepartment of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Yin-Tzer ShihDepartment of Applied Mathematics, National Chung Hsing University, Taichung, Taiwan.
I-Ta LeeSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/purpose: Particulate matter (PM) exposure is associated with inflammation and extracellular matrix degradation in periodontal tissues. Cyclooxygenase-2 (COX-2), prostaglandin E Materials and methods: Human gingival fibroblasts (HGF-1 cells) were exposed to PM, and the protective effects of nattokinase pretreatment were systematically evaluated. COX-2, PGE Results: PM stimulation induced COX-2 expression, PGE Conclusion: Nattokinase protects HGF-1 cells from PM-induced inflammation and matrix degradation by activating the Nrf2/HO-1 axis and suppressing NADPH oxidase-derived ROS, effectively interrupting the reciprocal regulation between ROS, PI3K/Akt, and MAPK pathways.

Indexed as

COX-2Gingival fibroblastsNattokinaseNrf2/HO-1Particulate matter

Identifiers

PMID41585176
PMCPMC12826023

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.