ArticleFrontiers in medicine2025
Comparison of the efficacy of thalidomide combined with low-dose rituximab and low-dose rituximab alone in the treatment of steroid-resistant/refractory adult patients with primary immune thrombocytopenia: an open-label trial.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Background: Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by reduced platelet counts, leading to an increased risk of bleeding and substantial impairment patients' quality of life. Although rituximab (RTX) is commonly employed as a second-line treatment for patients with steroid-refractory or steroid-resistant ITP, its long-term efficacy as monotherapy remains limited. Objective: This study aimed to evaluate the efficacy and safety of low-dose RTX (LD-RTX) in combination with thalidomide (THD) in the treatment of patients with steroid-refractory or steroid-dependent ITP. Method: A total of 100 patients with ITP who failed first-line treatment at Shangqiu First People's Hospital and Funing County People's Hospital between January 2021 and January 2025 were enrolled in a randomized controlled trial. Participants were assigned to one of two groups: the LD-RTX group (ctrl-group) or the T + LD-RTX group (thal-group). Results: The overall response rate in the thal-group was significantly higher than in the ctrl-group (79.17% vs. 55.32%; Conclusion: The combination of THD LD-RTX represents a promising therapeutic strategy for patients with steroid-refractory or steroid-dependent ITP. Furthermore, baseline NK cell levels may serve as a useful biomarker for predicting treatment response.
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