Evidence map›Paper›PMID 41585496›Full record

ArticleiScience2026

Preclinical drug screen identifies WEE1 inhibitor and vinca alkaloid as a combination treatment concept for Li-Fraumeni syndrome medulloblastoma.

Anna S Kolodziejczak, Florian Selt, Heike Peterziel, Nora Jamaladdin, Norman Mack, Kendra Maaß, Chris Meulenbroeks, Romain Sigaud, Christel Herold-Mende, Ahmed El Damaty and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Anna S KolodziejczakHopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany.
Florian SeltHopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany.
Heike PeterzielHopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany.
Nora JamaladdinHopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany.
Norman MackHopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany.
Kendra MaaßHopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany.
Chris MeulenbroeksPrincess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, the Netherlands.
Romain SigaudCCU Pediatric Oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.
Christel Herold-MendeDivision of Experimental Neurosurgery, Department of Neurosurgery, University of Heidelberg, Medical Faculty Heidelberg, 69120 Heidelberg, Germany.
Ahmed El DamatyPediatric Neurosurgery Division, Department of Neurosurgery, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Jürgen BurhenneDepartment of Clinical Pharmacology and Pharmacoepidemiology, Medical Faculty Heidelberg, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Shunya OhmuraHopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany.
Tim Holland-LetzDepartment of Biostatistics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Lena M KutscherHopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany.
Aurélie ErnstGroup Genome Instability in Tumors, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Pei-Chi WeiHeidelberg University, 69117 Heidelberg, Germany.
Thomas G P GrünewaldHopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany.
Ina OehmeHopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany.
Marcel KoolHopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany.
David T W JonesHopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany.
Kristian W PajtlerHopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany.
Christian P KratzPaediatric Haematology and Oncology, Hannover Medical School, 30625 Hannover, Germany.
Stefan M PfisterHopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany.
Olaf WittHopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany.
Till MildeHopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Li-Fraumeni syndrome (LFS) is characterized by constitutional pathogenic

Indexed as

Biological sciencesCancer systems biologyNatural sciencesPharmacologySystems biology

Identifiers

PMID41585496
PMCPMC12828543

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.