Evidence map›Paper›PMID 41585576›Full record

ReviewJGH open : an open access journal of gastroenterology and hepatology2026

Esophageal Perforation in Zollinger-Ellison Syndrome: A Scoping Review of Management and Outcomes.

Agostino Fernicola, Domenico Parmeggiani, Felice Crocetto, Armando Calogero, Alessio Cece, Domenico Romano, Giacomo Benassai, Gennaro Quarto, Michele Santangelo

Abstract readReview
In one paragraph

Review in JGH open : an open access journal of gastroenterology and hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Esophageal Perforation in Zollinger-Ellison Syndrome: A Scoping Review of Management and Outcomes.JGH open : an open access journal of gastroenterology and hepatology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Agostino FernicolaDepartment of Advanced Biomedical Sciences, Unit of Emergency Surgery Federico II University Naples Italy.ORCID https://orcid.org/0000-0002-3122-5531
Domenico ParmeggianiDepartment of Integrated Activities in Surgery, Orthopedy and Hepato-Gastroenterology University of Campania "Luigi Vanvitelli" Naples Italy.ORCID https://orcid.org/0000-0003-1926-5562
Felice CrocettoDepartment of Neurosciences, Sciences of Reproduction and Odontostomatology University Federico II Naples Italy.ORCID https://orcid.org/0000-0002-4315-7660
Armando CalogeroDepartment of Advanced Biomedical Sciences, Unit of Emergency Surgery Federico II University Naples Italy.ORCID https://orcid.org/0000-0003-2315-0610
Alessio CeceDepartment of Integrated Activities in Surgery, Orthopedy and Hepato-Gastroenterology University of Campania "Luigi Vanvitelli" Naples Italy.ORCID https://orcid.org/0009-0007-0151-8230
Domenico RomanoASL Naples 1, San Paolo Hospital Center Naples Italy.
Giacomo BenassaiDepartment of Clinical Medicine and Surgery Federico II University Naples Italy.
Gennaro QuartoDepartment of Clinical Medicine and Surgery Federico II University Naples Italy.ORCID https://orcid.org/0000-0001-5699-150X
Michele SantangeloDepartment of Advanced Biomedical Sciences, Unit of Emergency Surgery Federico II University Naples Italy.ORCID https://orcid.org/0000-0003-1299-9192

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Esophageal perforation in Zollinger-Ellison syndrome (ZES) is an exceedingly rare and life-threatening manifestation of gastrinoma-related acid hypersecretion. While peptic ulceration and severe reflux are recognized complications of ZES, perforation represents the ultimate consequence of uncontrolled hyperacidity. Evidence remains confined to isolated case reports with no prior systematic synthesis. A scoping review was conducted in accordance with PRISMA-ScR and the Joanna Briggs Institute framework. A comprehensive search of PubMed, Embase, Scopus, and Web of Science was performed from database inception to September 2025. Eligible studies included any report describing esophageal perforation in confirmed or suspected ZES. Iatrogenic perforations were excluded. Data were extracted on patient demographics, clinical presentation, diagnostic modalities, management strategies, and outcomes.

Indexed as

acid hypersecretionBoerhaave syndromeesophageal perforationgastrinomaZollinger–Ellison syndrome

Identifiers

PMID41585576
PMCPMC12827053

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.